ID   FIBIN_HUMAN             Reviewed;         211 AA.
AC   Q8TAL6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Fin bud initiation factor homolog;
DE   Flags: Precursor;
GN   Name=FIBIN; ORFNames=PSEC0235;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=17196583; DOI=10.1016/j.ydbio.2006.11.041;
RA   Wakahara T., Kusu N., Yamauchi H., Kimura I., Konishi M., Miyake A.,
RA   Itoh N.;
RT   "Fibin, a novel secreted lateral plate mesoderm signal, is essential for
RT   pectoral fin bud initiation in zebrafish.";
RL   Dev. Biol. 303:527-535(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA   Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA   Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA   Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA   Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA   Isogai T.;
RT   "Signal sequence and keyword trap in silico for selection of full-length
RT   human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT   libraries.";
RL   DNA Res. 12:117-126(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PROTEIN SEQUENCE OF 19-21, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-30,
RP   SUBUNIT, AND DISULFIDE BONDS.
RX   PubMed=21615908; DOI=10.1186/1471-2091-12-26;
RA   Lakner J., Seyer C., Hermsdorf T., Schoneberg T.;
RT   "Characterization of the expression, promoter activity and molecular
RT   architecture of fibin.";
RL   BMC Biochem. 12:26-26(2011).
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Seems to also exist as monomers.
CC       {ECO:0000269|PubMed:21615908}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Golgi apparatus
CC       {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:21615908}.
CC   -!- SIMILARITY: Belongs to the FIBIN family. {ECO:0000305}.
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DR   EMBL; AB236892; BAF42654.1; -; mRNA.
DR   EMBL; AK075535; BAC11678.1; -; mRNA.
DR   EMBL; CH471064; EAW68292.1; -; Genomic_DNA.
DR   EMBL; BC026873; AAH26873.1; -; mRNA.
DR   CCDS; CCDS7861.1; -.
DR   RefSeq; NP_976249.1; NM_203371.1.
DR   AlphaFoldDB; Q8TAL6; -.
DR   BioGRID; 132428; 84.
DR   STRING; 9606.ENSP00000321962; -.
DR   GlyGen; Q8TAL6; 1 site.
DR   iPTMnet; Q8TAL6; -.
DR   PhosphoSitePlus; Q8TAL6; -.
DR   BioMuta; FIBIN; -.
DR   DMDM; 74730366; -.
DR   jPOST; Q8TAL6; -.
DR   MassIVE; Q8TAL6; -.
DR   PaxDb; Q8TAL6; -.
DR   PeptideAtlas; Q8TAL6; -.
DR   PRIDE; Q8TAL6; -.
DR   ProteomicsDB; 73891; -.
DR   Antibodypedia; 25393; 66 antibodies from 17 providers.
DR   DNASU; 387758; -.
DR   Ensembl; ENST00000318627.4; ENSP00000321962.2; ENSG00000176971.4.
DR   GeneID; 387758; -.
DR   KEGG; hsa:387758; -.
DR   MANE-Select; ENST00000318627.4; ENSP00000321962.2; NM_203371.2; NP_976249.1.
DR   UCSC; uc001mrd.4; human.
DR   CTD; 387758; -.
DR   DisGeNET; 387758; -.
DR   GeneCards; FIBIN; -.
DR   HGNC; HGNC:33747; FIBIN.
DR   HPA; ENSG00000176971; Low tissue specificity.
DR   neXtProt; NX_Q8TAL6; -.
DR   OpenTargets; ENSG00000176971; -.
DR   PharmGKB; PA164720070; -.
DR   VEuPathDB; HostDB:ENSG00000176971; -.
DR   eggNOG; ENOG502QSW0; Eukaryota.
DR   GeneTree; ENSGT00390000007623; -.
DR   HOGENOM; CLU_1323584_0_0_1; -.
DR   InParanoid; Q8TAL6; -.
DR   OMA; GFFCHLC; -.
DR   OrthoDB; 1323802at2759; -.
DR   PhylomeDB; Q8TAL6; -.
DR   TreeFam; TF331989; -.
DR   PathwayCommons; Q8TAL6; -.
DR   SignaLink; Q8TAL6; -.
DR   BioGRID-ORCS; 387758; 7 hits in 1069 CRISPR screens.
DR   ChiTaRS; FIBIN; human.
DR   GenomeRNAi; 387758; -.
DR   Pharos; Q8TAL6; Tbio.
DR   PRO; PR:Q8TAL6; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8TAL6; protein.
DR   Bgee; ENSG00000176971; Expressed in calcaneal tendon and 166 other tissues.
DR   Genevisible; Q8TAL6; HS.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0070528; P:protein kinase C signaling; IEA:Ensembl.
DR   GO; GO:0071548; P:response to dexamethasone; IEA:Ensembl.
DR   GO; GO:0010042; P:response to manganese ion; IEA:Ensembl.
DR   InterPro; IPR026772; Fibin.
DR   PANTHER; PTHR31185; PTHR31185; 1.
DR   Pfam; PF15819; Fibin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Endoplasmic reticulum;
KW   Glycoprotein; Golgi apparatus; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:21615908"
FT   CHAIN           19..211
FT                   /note="Fin bud initiation factor homolog"
FT                   /id="PRO_0000349211"
FT   CARBOHYD        30
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:21615908"
FT   DISULFID        52
FT                   /note="Interchain"
FT                   /evidence="ECO:0000269|PubMed:21615908"
FT   DISULFID        64
FT                   /note="Interchain"
FT                   /evidence="ECO:0000269|PubMed:21615908"
SQ   SEQUENCE   211 AA;  24273 MW;  A808B3D2E23E732D CRC64;
     MVFLKFFCMS FFCHLCQGYF DGPLYPEMSN GTLHHYFVPD GDYEENDDPE KCQLLFRVSD
     HRRCSQGEGS QVGSLLSLTL REEFTVLGRQ VEDAGRVLEG ISKSISYDLD GEESYGKYLR
     RESHQIGDAY SNSDKSLTEL ESKFKQGQEQ DSRQESRLNE DFLGMLVHTR SLLKETLDIS
     VGLRDKYELL ALTIRSHGTR LGRLKNDYLK V