FIBIN_MOUSE
ID FIBIN_MOUSE Reviewed; 217 AA.
AC Q9CQS3;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Fin bud initiation factor homolog;
DE Flags: Precursor;
GN Name=Fibin;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=17196583; DOI=10.1016/j.ydbio.2006.11.041;
RA Wakahara T., Kusu N., Yamauchi H., Kimura I., Konishi M., Miyake A.,
RA Itoh N.;
RT "Fibin, a novel secreted lateral plate mesoderm signal, is essential for
RT pectoral fin bud initiation in zebrafish.";
RL Dev. Biol. 303:527-535(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Homodimer; disulfide-linked. Seems to also exist as monomers
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Golgi apparatus
CC {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: At 9.5 dpc and 10.5 dpc, abundantly expressed in
CC the forelimb buds. {ECO:0000269|PubMed:17196583}.
CC -!- SIMILARITY: Belongs to the FIBIN family. {ECO:0000305}.
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DR EMBL; AB236893; BAF42655.1; -; mRNA.
DR EMBL; AK003790; BAB22997.1; -; mRNA.
DR EMBL; AK011548; BAB27691.1; -; mRNA.
DR EMBL; AK012026; BAB27982.1; -; mRNA.
DR EMBL; AK159648; BAE35260.1; -; mRNA.
DR EMBL; AL691416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027250; AAH27250.1; -; mRNA.
DR CCDS; CCDS16511.1; -.
DR RefSeq; NP_080547.1; NM_026271.1.
DR AlphaFoldDB; Q9CQS3; -.
DR SMR; Q9CQS3; -.
DR BioGRID; 212307; 2.
DR STRING; 10090.ENSMUSP00000097221; -.
DR GlyGen; Q9CQS3; 1 site.
DR PhosphoSitePlus; Q9CQS3; -.
DR PaxDb; Q9CQS3; -.
DR PRIDE; Q9CQS3; -.
DR ProteomicsDB; 266844; -.
DR Antibodypedia; 25393; 66 antibodies from 17 providers.
DR DNASU; 67606; -.
DR Ensembl; ENSMUST00000099626; ENSMUSP00000097221; ENSMUSG00000074971.
DR GeneID; 67606; -.
DR KEGG; mmu:67606; -.
DR UCSC; uc008lmv.1; mouse.
DR CTD; 387758; -.
DR MGI; MGI:1914856; Fibin.
DR VEuPathDB; HostDB:ENSMUSG00000074971; -.
DR eggNOG; ENOG502QSW0; Eukaryota.
DR GeneTree; ENSGT00390000007623; -.
DR HOGENOM; CLU_1323584_0_0_1; -.
DR InParanoid; Q9CQS3; -.
DR OMA; GFFCHLC; -.
DR OrthoDB; 1323802at2759; -.
DR PhylomeDB; Q9CQS3; -.
DR TreeFam; TF331989; -.
DR BioGRID-ORCS; 67606; 4 hits in 74 CRISPR screens.
DR PRO; PR:Q9CQS3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CQS3; protein.
DR Bgee; ENSMUSG00000074971; Expressed in humerus cartilage element and 157 other tissues.
DR Genevisible; Q9CQS3; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0070528; P:protein kinase C signaling; IEP:UniProtKB.
DR GO; GO:0071548; P:response to dexamethasone; IEP:UniProtKB.
DR GO; GO:0010042; P:response to manganese ion; IEP:UniProtKB.
DR InterPro; IPR026772; Fibin.
DR PANTHER; PTHR31185; PTHR31185; 1.
DR Pfam; PF15819; Fibin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Endoplasmic reticulum; Glycoprotein; Golgi apparatus;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000250"
FT CHAIN 19..217
FT /note="Fin bud initiation factor homolog"
FT /id="PRO_0000349212"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 52
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 64
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 217 AA; 24760 MW; 62CBA326432D5C49 CRC64;
MVFPKLIWMG FFCHLCRGYF DGPLYPEMSN GTLHHYFVPD GDYEENDDPE KCQLLFRVSD
RRRCSQGEGG QASSLLSLTL REEFTVLGRQ VEDAGRVLEG ISKSISYDLD GEESYGKYLR
RESHQIGDAY SNSDKSLTEL ESKFKQGQEQ DSRQESRLNE DFLGMLVHTR SLLKETLDIS
VGLRDKYELL AHTIRSHGTR LGRLKSDYLE GGAQKTG
