ID   FIBP_CHLAE              Reviewed;         357 AA.
AC   O46431;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Acidic fibroblast growth factor intracellular-binding protein;
DE            Short=aFGF intracellular-binding protein;
DE   AltName: Full=FGF-1 intracellular-binding protein;
GN   Name=FIBP;
OS   Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=9534;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   PubMed=9806903; DOI=10.1042/bj3360213;
RA   Kolpakova E., Wiedlocha A., Stenmark H., Klingenberg O., Falnes P.O.,
RA   Olsnes S.;
RT   "Cloning of an intracellular protein that binds selectively to mitogenic
RT   acidic fibroblast growth factor.";
RL   Biochem. J. 336:213-222(1998).
CC   -!- FUNCTION: May be involved in mitogenic function of FGF1 (By
CC       similarity). May mediate with IER2 FGF-signaling in the establishment
CC       of laterality in the embryo (By similarity).
CC       {ECO:0000250|UniProtKB:O43427, ECO:0000250|UniProtKB:Q6T938}.
CC   -!- SUBUNIT: Binds to internalized FGF1; this interaction is increased in
CC       the presence of CSNKB, suggesting a possible cooperative interaction
CC       between CSNKB and FIBP in binding to FGF1.
CC       {ECO:0000250|UniProtKB:O43427}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43427}.
CC       Endomembrane system {ECO:0000250|UniProtKB:O43427}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:O43427}. Note=Also associated with
CC       cytoplasmic membranes, particularly of mitochondria.
CC       {ECO:0000250|UniProtKB:O43427}.
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DR   EMBL; AF010188; AAC97141.2; -; mRNA.
DR   AlphaFoldDB; O46431; -.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008614; FIBP.
DR   PANTHER; PTHR13223; PTHR13223; 1.
DR   Pfam; PF05427; FIBP; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Nucleus.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O43427"
FT   CHAIN           2..357
FT                   /note="Acidic fibroblast growth factor intracellular-
FT                   binding protein"
FT                   /id="PRO_0000087236"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O43427"
SQ   SEQUENCE   357 AA;  41210 MW;  259F5181185CB0ED CRC64;
     MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA VLQSDTMDHY
     RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD EAFVREVLGK KLSKGTKKDL
     DDISTKTGIT LKSCRRQFDN FKRVFKVVEE MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA
     NNRFETGKKK LQYLSFGDFA FCAELMIQNW TLGAVDSQMD DMDMDLDKEF LQDLKELKVL
     VADKDLLDLH KSLVCTALRG KLGVFSEMEA NFKNLSRGLV NVAAKLTHNK DVRDLFVDLV
     EKFVEPCRSD HWPLSDVRFF LNQYSASVHS LDGFRHQALW DRYMGTLRGC LLRLYHD