ID   AKH1_LOCMI              Reviewed;          63 AA.
AC   P55319; P01271; P10616;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Adipokinetic prohormone type 1;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone 1;
DE     AltName: Full=Adipokinetic hormone I;
DE              Short=AKH-I;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone precursor-related peptide alpha chain;
DE              Short=APRP-alpha;
DE     AltName: Full=6 kDa dimeric peptide A;
DE   Flags: Precursor;
OS   Locusta migratoria (Migratory locust).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Oedipodinae; Locusta.
OX   NCBI_TaxID=7004;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Corpora cardiaca;
RX   PubMed=7559443; DOI=10.1074/jbc.270.39.23038;
RA   Bogerd J., Kooiman F.P., Pijnenburg M.A.P., Hekking L.H., Oudejans R.C.,
RA   Vander Horst D.J.;
RT   "Molecular cloning of three distinct cDNAs, each encoding a different
RT   adipokinetic hormone precursor, of the migratory locust, Locusta
RT   migratoria. Differential expression of the distinct adipokinetic hormone
RT   precursor genes during flight activity.";
RL   J. Biol. Chem. 270:23038-23043(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 23-32, FUNCTION, PYROGLUTAMATE FORMATION AT GLN-23, AND
RP   AMIDATION AT THR-32.
RX   PubMed=958472; DOI=10.1038/263207a0;
RA   Stone J.V., Mordue W., Batley K.E., Morris H.R.;
RT   "Structure of locust adipokinetic hormone, a neurohormone that regulates
RT   lipid utilisation during flight.";
RL   Nature 263:207-211(1976).
RN   [3]
RP   PROTEIN SEQUENCE OF 26-32.
RX   PubMed=8224763; DOI=10.1006/gcen.1993.1092;
RA   Schoofs L., Holman G.M., Proost P., van Damme J., Neven H., Oudejans R.C.,
RA   de Loof A.;
RT   "Isolation, identification, and synthesis of AKH-I4-10 from Locusta
RT   migratoria.";
RL   Gen. Comp. Endocrinol. 90:364-371(1993).
RN   [4]
RP   PROTEIN SEQUENCE OF 36-63.
RX   PubMed=2731552; DOI=10.1111/j.1432-1033.1989.tb14802.x;
RA   Hietter H., Luu B., Goltzene F., Zachary D., Hoffmann J.A.,
RA   van Dorsselaer A.;
RT   "Isolation and structure of two novel 6-kDa dimeric peptides from the
RT   corpora cardiaca of the insect Locusta migratoria. Molecular mass
RT   determination by mass spectrometry.";
RL   Eur. J. Biochem. 182:77-84(1989).
CC   -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC       causes release of diglycerides from the fat body and stimulation of
CC       muscles to use these diglycerides as an energy source during energy-
CC       demanding processes. {ECO:0000269|PubMed:958472}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X86799; CAA60494.1; -; mRNA.
DR   PIR; A58652; AKLQ.
DR   AlphaFoldDB; P55319; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   InterPro; IPR010475; AKH/RPCH_hormone.
DR   Pfam; PF06377; Adipokin_hormo; 1.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Flight; Hormone; Neuropeptide; Pyrrolidone carboxylic acid;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:958472"
FT   CHAIN           23..63
FT                   /note="Adipokinetic prohormone type 1"
FT                   /id="PRO_0000000905"
FT   PEPTIDE         23..32
FT                   /note="Adipokinetic hormone 1"
FT                   /id="PRO_0000000906"
FT   PEPTIDE         36..63
FT                   /note="Adipokinetic hormone precursor-related peptide alpha
FT                   chain"
FT                   /id="PRO_0000000907"
FT   MOD_RES         23
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:958472"
FT   MOD_RES         32
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000269|PubMed:958472"
FT   DISULFID        61
FT                   /note="Interchain"
SQ   SEQUENCE   63 AA;  6824 MW;  D7D4DD01252E8CAD CRC64;
     MVQRCALVVL LVVAVAAALC SAQLNFTPNW GTGKRDAADF ADPYSFLYRL IQAEARKMSG
     CSN