FIBP_DANRE
ID FIBP_DANRE Reviewed; 355 AA.
AC Q6T938;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Acidic fibroblast growth factor intracellular-binding protein B;
DE Short=aFGF intracellular-binding protein B;
DE AltName: Full=FGF-1 intracellular-binding protein B;
GN Name=fibpb {ECO:0000312|ZFIN:ZDB-GENE-040630-2};
GN Synonyms=fibpl {ECO:0000312|ZFIN:ZDB-GENE-040630-2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Joseph E.M., Fishman M.C.;
RT "Zebrafish aFGF intracellular binding protein (FIBP) gene maps to linkage
RT group 21.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary {ECO:0000312|EMBL:AAH85535.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH IER2, DISRUPTION
RP PHENOTYPE, AND DEVELOPMENTAL STAGE.
RX PubMed=19164561; DOI=10.1073/pnas.0812880106;
RA Hong S.K., Dawid I.B.;
RT "FGF-dependent left-right asymmetry patterning in zebrafish is mediated by
RT Ier2 and Fibp1.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:2230-2235(2009).
CC -!- FUNCTION: Mediates with IER2 FGF-signaling in Kupffer's vesicle
CC ciliogenesis and in the establishment of laterality in the embryo
CC (PubMed:19164561). May be involved in mitogenic function of FGF1 (By
CC similarity). {ECO:0000250|UniProtKB:O43427,
CC ECO:0000269|PubMed:19164561}.
CC -!- SUBUNIT: Interacts with IER2. {ECO:0000269|PubMed:19164561}.
CC -!- INTERACTION:
CC Q6T938; B7SXM5: ier2; NbExp=3; IntAct=EBI-15752740, EBI-15752758;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19164561}.
CC Endomembrane system {ECO:0000250|UniProtKB:O43427}; Peripheral membrane
CC protein {ECO:0000250|UniProtKB:O43427}.
CC -!- DEVELOPMENTAL STAGE: Expressed ubiquitously.
CC {ECO:0000305|PubMed:19164561}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes severe
CC deficits in laterality (PubMed:19164561). Partial loss of Kupffer's
CC vesicle cilia with the length of the remaining cilia reduced
CC (PubMed:19164561). Double morpholino knockdown of IER2 and FIBPB causes
CC an almost complete loss of Kupffer's vesicle cilia (PubMed:19164561).
CC {ECO:0000269|PubMed:19164561}.
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DR EMBL; AY427781; AAR23113.1; -; mRNA.
DR EMBL; BC085535; AAH85535.1; -; mRNA.
DR EMBL; FP236853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_998026.1; NM_212861.2.
DR AlphaFoldDB; Q6T938; -.
DR DIP; DIP-48705N; -.
DR IntAct; Q6T938; 1.
DR STRING; 7955.ENSDARP00000119615; -.
DR PaxDb; Q6T938; -.
DR DNASU; 405787; -.
DR GeneID; 405787; -.
DR KEGG; dre:405787; -.
DR CTD; 405787; -.
DR ZFIN; ZDB-GENE-040630-2; fibpb.
DR eggNOG; ENOG502QPQ2; Eukaryota.
DR PhylomeDB; Q6T938; -.
DR TreeFam; TF323763; -.
DR PRO; PR:Q6T938; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IGI:ZFIN.
DR GO; GO:0017134; F:fibroblast growth factor binding; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR GO; GO:0060026; P:convergent extension; IMP:ZFIN.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
DR GO; GO:0070121; P:Kupffer's vesicle development; IMP:ZFIN.
DR InterPro; IPR008614; FIBP.
DR PANTHER; PTHR13223; PTHR13223; 1.
DR Pfam; PF05427; FIBP; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Reference proteome.
FT CHAIN 1..355
FT /note="Acidic fibroblast growth factor intracellular-
FT binding protein B"
FT /id="PRO_0000433930"
SQ SEQUENCE 355 AA; 41101 MW; F352D6F979A48F9F CRC64;
MELDVFVGNT TVLDEDIYQL WLDGHSVSDV VRQRMDAGVL LECEASPDVL QSDTIDQFRT
FQMCERLLQS PSKVANQLLF QIPSDQQAML IERYYEFDSV FAREVLGKKL SKGTKKDLDD
VSAKTGIALK SCRRQFDNFK RVFKVVEELK GPLVENIQRH FLLSDDLARD YATIVFFANS
RFETGKRKLQ YLSFQDFAFC AGQLISYWTV GAVDNMIEDM DVDLEKDFLH DLKDLKVLVN
DKDLLDQHKS LVCGQLRGKI KVFNEMEASF KNLSRALVNI ASKLTHAKDV RDLFIDLVEK
FIEPCRSDKW TSGDLRLFLT HYSTSVHTLE AFRHQVIWDR YMGVIKSCIL KMYHD
