FIBP_MOUSE
ID FIBP_MOUSE Reviewed; 357 AA.
AC Q9JI19;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Acidic fibroblast growth factor intracellular-binding protein;
DE Short=aFGF intracellular-binding protein;
DE AltName: Full=FGF-1 intracellular-binding protein;
GN Name=Fibp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=11104667; DOI=10.1042/bj3520629;
RA Kolpakova E., Frengen E., Stokke T., Olsnes S.;
RT "Organization, chromosomal localization and promoter analysis of the gene
RT encoding human acidic fibroblast growth factor intracellular binding
RT protein.";
RL Biochem. J. 352:629-635(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=27183861; DOI=10.1002/ajmg.a.37741;
RA Akawi N., Ben-Salem S., Lahti L., Partanen J., Ali B.R., Al-Gazali L.;
RT "A recessive syndrome of intellectual disability, moderate overgrowth, and
RT renal dysplasia predisposing to Wilms tumor is caused by a mutation in FIBP
RT gene.";
RL Am. J. Med. Genet. A 170:2111-2118(2016).
CC -!- FUNCTION: May be involved in mitogenic function of FGF1 (By
CC similarity). May mediate with IER2 FGF-signaling in the establishment
CC of laterality in the embryo (By similarity).
CC {ECO:0000250|UniProtKB:O43427, ECO:0000250|UniProtKB:Q6T938}.
CC -!- SUBUNIT: Binds to internalized FGF1; this interaction is increased in
CC the presence of CSNKB, suggesting a possible cooperative interaction
CC between CSNKB and FIBP in binding to FGF1.
CC {ECO:0000250|UniProtKB:O43427}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43427}.
CC Endomembrane system {ECO:0000250|UniProtKB:O43427}; Peripheral membrane
CC protein {ECO:0000250}. Note=Also associated with cytoplasmic membranes,
CC particularly of mitochondria. {ECO:0000250|UniProtKB:O43427}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the development in embryo at
CC 10.5 dpc. Expressed in the central nervous system at 12.5 dpc.
CC Expressed in the ventral part of caudal diencephalon at 12.5 dpc.
CC Expressed in the dorsal root ganglia at 12.5 dpc. Expressed in the
CC kidney and lung at 12.5 dpc. Expressed in the dorsal and ventral
CC midbrain at 18.5 dpc. Expressed uniformely in the cortex at 18.5 dpc.
CC {ECO:0000269|PubMed:27183861}.
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DR EMBL; AF270700; AAF76201.1; -; mRNA.
DR EMBL; AK012629; BAB28367.1; -; mRNA.
DR EMBL; AK028029; BAC25708.1; -; mRNA.
DR CCDS; CCDS89310.1; -.
DR RefSeq; NP_067413.1; NM_021438.4.
DR AlphaFoldDB; Q9JI19; -.
DR BioGRID; 208419; 7.
DR IntAct; Q9JI19; 1.
DR STRING; 10090.ENSMUSP00000025847; -.
DR iPTMnet; Q9JI19; -.
DR PhosphoSitePlus; Q9JI19; -.
DR EPD; Q9JI19; -.
DR MaxQB; Q9JI19; -.
DR PaxDb; Q9JI19; -.
DR PRIDE; Q9JI19; -.
DR ProteomicsDB; 266845; -.
DR Antibodypedia; 1859; 195 antibodies from 25 providers.
DR DNASU; 58249; -.
DR Ensembl; ENSMUST00000225141; ENSMUSP00000153409; ENSMUSG00000024911.
DR GeneID; 58249; -.
DR KEGG; mmu:58249; -.
DR UCSC; uc008gdg.2; mouse.
DR CTD; 9158; -.
DR MGI; MGI:1926233; Fibp.
DR VEuPathDB; HostDB:ENSMUSG00000024911; -.
DR eggNOG; ENOG502QPQ2; Eukaryota.
DR GeneTree; ENSGT00390000015815; -.
DR InParanoid; Q9JI19; -.
DR BioGRID-ORCS; 58249; 8 hits in 70 CRISPR screens.
DR ChiTaRS; Fibp; mouse.
DR PRO; PR:Q9JI19; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9JI19; protein.
DR Bgee; ENSMUSG00000024911; Expressed in embryonic brain and 271 other tissues.
DR ExpressionAtlas; Q9JI19; baseline and differential.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0017134; F:fibroblast growth factor binding; ISO:MGI.
DR InterPro; IPR008614; FIBP.
DR PANTHER; PTHR13223; PTHR13223; 1.
DR Pfam; PF05427; FIBP; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O43427"
FT CHAIN 2..357
FT /note="Acidic fibroblast growth factor intracellular-
FT binding protein"
FT /id="PRO_0000087238"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000250|UniProtKB:O43427"
SQ SEQUENCE 357 AA; 41204 MW; 51A6D28F5879D94B CRC64;
MTSELDIFVG NTTLIDEDVY RLWLDGYSVN DAVALRVRSG ILEQTGATTG VLQSDTMDHY
RTFHMLERLL HAPPKLLHQL IFQIPPSRQT LLIERYYTFD EAFVREVLGK KLSKGTKKDL
DDISTKTGIT LKSCRRQFDN FKRVFKVVEE MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA
NNRFETGKKK LQYLSFGDFA FCAELMIQNW TLGAVDSQVD DMDVDLDKEF LQDLKELKVL
VADKDLLDLH KSLVCTALRG KLGVFSEMET NFKNLSRGLV NVAAKLTHNK DVRDLFVDLV
EKFVEPCRSD HWPLSDVRLF LSQYSASVHS LDGFRHQALW DRYMGTLRGC LLRLYHD
