ID   AKH1_SCHGR              Reviewed;          63 AA.
AC   P18829;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Adipokinetic prohormone type 1;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone 1;
DE     AltName: Full=Adipokinetic hormone I;
DE              Short=AKH-I;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone I4-10;
DE              Short=AKH-I4-10;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone precursor-related peptide alpha chain;
DE              Short=APRP-alpha;
DE   Flags: Precursor;
OS   Schistocerca gregaria (Desert locust) (Gryllus gregarius).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX   NCBI_TaxID=7010;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2576372; DOI=10.1016/0896-6273(89)90075-5;
RA   Schulz-Aellen M.F., Roulet E., Fischer-Lougheed J., O'Shea M.;
RT   "Synthesis of a homodimer neurohormone precursor of locust adipokinetic
RT   hormone studied by in vitro translation and cDNA cloning.";
RL   Neuron 2:1369-1373(1989).
RN   [2]
RP   PROTEIN SEQUENCE OF 23-63.
RX   PubMed=2627375; DOI=10.1016/0896-6273(89)90074-3;
RA   Hekimi S., Burkhart W., Moyer M., Fowler E., O'Shea M.;
RT   "Dimer structure of a neuropeptide precursor established: consequences for
RT   processing.";
RL   Neuron 2:1363-1368(1989).
RN   [3]
RP   PROTEIN SEQUENCE OF 23-32, PYROGLUTAMATE FORMATION AT GLN-23, AND AMIDATION
RP   AT THR-32.
RX   PubMed=958472; DOI=10.1038/263207a0;
RA   Stone J.V., Mordue W., Batley K.E., Morris H.R.;
RT   "Structure of locust adipokinetic hormone, a neurohormone that regulates
RT   lipid utilisation during flight.";
RL   Nature 263:207-211(1976).
RN   [4]
RP   PROTEOLYTIC PROCESSING.
RX   PubMed=1941082; DOI=10.1523/jneurosci.11-10-03246.1991;
RA   Hekimi S., Fischer-Lougheed J., O'Shea M.;
RT   "Regulation of neuropeptide stoichiometry in neurosecretory cells.";
RL   J. Neurosci. 11:3246-3256(1991).
CC   -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC       causes release of diglycerides from the fat body and stimulation of
CC       muscles to use these diglycerides as an energy source during energy-
CC       demanding processes.
CC   -!- SUBUNIT: Adipokinetic hormone precursor-related peptide (APRP) can form
CC       three type of disulfide-bond dimers: p1 (alpha-alpha), p2 (alpha-beta),
CC       and p3 (beta-beta).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; A93412; AKLQS.
DR   AlphaFoldDB; P18829; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   InterPro; IPR010475; AKH/RPCH_hormone.
DR   Pfam; PF06377; Adipokin_hormo; 1.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Flight; Hormone; Neuropeptide; Pyrrolidone carboxylic acid;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:2627375,
FT                   ECO:0000269|PubMed:958472"
FT   CHAIN           23..63
FT                   /note="Adipokinetic prohormone type 1"
FT                   /id="PRO_0000000916"
FT   PEPTIDE         23..32
FT                   /note="Adipokinetic hormone 1"
FT                   /id="PRO_0000000917"
FT   PEPTIDE         26..32
FT                   /note="Adipokinetic hormone I4-10"
FT                   /id="PRO_0000000918"
FT   PEPTIDE         36..63
FT                   /note="Adipokinetic hormone precursor-related peptide alpha
FT                   chain"
FT                   /id="PRO_0000000919"
FT   MOD_RES         23
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:958472"
FT   MOD_RES         32
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000269|PubMed:958472"
FT   DISULFID        61
FT                   /note="Interchain"
SQ   SEQUENCE   63 AA;  6838 MW;  0BCDFAADF073914B CRC64;
     MVQRCLVVAL LVVVVAAALC SAQLNFTPNW GTGKRDAADF GDPYSFLYRL IQAEARKMSG
     CSN