ID   AKH1_SCHNI              Reviewed;          63 AA.
AC   P18830; P01271;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Adipokinetic prohormone type 1;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone 1;
DE     AltName: Full=Adipokinetic hormone I;
DE              Short=AKH-I;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone precursor-related peptide alpha chain;
DE              Short=APRP-alpha;
DE   Flags: Precursor;
OS   Schistocerca nitens (Vagrant locust) (Gray bird grasshopper).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX   NCBI_TaxID=7011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2294116; DOI=10.1016/s0021-9258(19)40256-1;
RA   Noyes B.E., Schaffer M.H.;
RT   "The structurally similar neuropeptides adipokinetic hormone I and II are
RT   derived from similar, very small mRNAs.";
RL   J. Biol. Chem. 265:483-489(1990).
CC   -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC       causes release of diglycerides from the fat body and stimulation of
CC       muscles to use these diglycerides as an energy source during energy-
CC       demanding processes.
CC   -!- SUBUNIT: Adipokinetic hormone precursor-related peptide (APRP) can form
CC       three type of disulfide-bond dimers: p1 (alpha-alpha), p2 (alpha-beta),
CC       and p3 (beta-beta).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   EMBL; L08772; AAC18873.1; -; Genomic_DNA.
DR   EMBL; L08771; AAC18873.1; JOINED; Genomic_DNA.
DR   EMBL; J05170; AAA73931.1; -; mRNA.
DR   PIR; A34913; A34913.
DR   AlphaFoldDB; P18830; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   InterPro; IPR010475; AKH/RPCH_hormone.
DR   Pfam; PF06377; Adipokin_hormo; 1.
DR   PROSITE; PS00256; AKH; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Flight;
KW   Hormone; Neuropeptide; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..63
FT                   /note="Adipokinetic prohormone type 1"
FT                   /id="PRO_0000000923"
FT   PEPTIDE         23..32
FT                   /note="Adipokinetic hormone 1"
FT                   /id="PRO_0000000924"
FT   PEPTIDE         36..63
FT                   /note="Adipokinetic hormone precursor-related peptide alpha
FT                   chain"
FT                   /id="PRO_0000000925"
FT   MOD_RES         23
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         32
FT                   /note="Threonine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        61
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   63 AA;  6840 MW;  5A249ACBF073915D CRC64;
     MVQRCLVVAL LVVVVAAALC SAQLNFTPNW GTGKRDAGDY GDPYSFLYRL IQAEARKMSG
     CSN