ID   3MGH_MYCTU              Reviewed;         203 AA.
AC   P9WJP7; L0TAC1; O33190; P65412;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
DE            EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
GN   OrderedLocusNames=Rv1688; ORFNames=MTCI125.10;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00527}.
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DR   EMBL; AL123456; CCP44453.1; -; Genomic_DNA.
DR   PIR; G70501; G70501.
DR   RefSeq; NP_216204.1; NC_000962.3.
DR   RefSeq; WP_003408373.1; NZ_NVQJ01000010.1.
DR   AlphaFoldDB; P9WJP7; -.
DR   SMR; P9WJP7; -.
DR   STRING; 83332.Rv1688; -.
DR   PaxDb; P9WJP7; -.
DR   DNASU; 885679; -.
DR   GeneID; 45425657; -.
DR   GeneID; 885679; -.
DR   KEGG; mtu:Rv1688; -.
DR   TubercuList; Rv1688; -.
DR   eggNOG; COG2094; Bacteria.
DR   OMA; VEAYHHT; -.
DR   PhylomeDB; P9WJP7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IBA:GO_Central.
DR   CDD; cd00540; AAG; 1.
DR   Gene3D; 3.10.300.10; -; 1.
DR   HAMAP; MF_00527; 3MGH; 1.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR003180; MPG.
DR   InterPro; IPR036995; MPG_sf.
DR   PANTHER; PTHR10429; PTHR10429; 1.
DR   Pfam; PF02245; Pur_DNA_glyco; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   TIGRFAMs; TIGR00567; 3mg; 1.
PE   1: Evidence at protein level;
KW   DNA damage; DNA repair; Hydrolase; Reference proteome.
FT   CHAIN           1..203
FT                   /note="Putative 3-methyladenine DNA glycosylase"
FT                   /id="PRO_0000100094"
SQ   SEQUENCE   203 AA;  21340 MW;  9DFE3035819504B0 CRC64;
     MNAEELAIDP VAAAHRLLGA TIAGRGVRAM VVEVEAYGGV PDGPWPDAAA HSYRGRNGRN
     DVMFGPPGRL YTYRSHGIHV CANVACGPDG TAAAVLLRAA AIEDGAELAT SRRGQTVRAV
     ALARGPGNLC AALGITMADN GIDLFDPSSP VRLRLNDTHR ARSGPRVGVS QAADRPWRLW
     LTGRPEVSAY RRSSRAPARG ASD