AKH2_LOCMI
ID AKH2_LOCMI Reviewed; 61 AA.
AC P08379; P10617;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 3.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Adipokinetic prohormone type 2;
DE Contains:
DE RecName: Full=Adipokinetic hormone 2;
DE AltName: Full=Adipokinetic hormone II;
DE Short=AKH-II;
DE Contains:
DE RecName: Full=Adipokinetic hormone precursor-related peptide beta chain;
DE Short=APRP-beta;
DE AltName: Full=6 kDa dimeric peptide B;
DE Flags: Precursor;
OS Locusta migratoria (Migratory locust).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC Acridoidea; Acrididae; Oedipodinae; Locusta.
OX NCBI_TaxID=7004;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Corpora cardiaca;
RX PubMed=7559443; DOI=10.1074/jbc.270.39.23038;
RA Bogerd J., Kooiman F.P., Pijnenburg M.A.P., Hekking L.H., Oudejans R.C.,
RA Vander Horst D.J.;
RT "Molecular cloning of three distinct cDNAs, each encoding a different
RT adipokinetic hormone precursor, of the migratory locust, Locusta
RT migratoria. Differential expression of the distinct adipokinetic hormone
RT precursor genes during flight activity.";
RL J. Biol. Chem. 270:23038-23043(1995).
RN [2]
RP PROTEIN SEQUENCE OF 23-30, PYROGLUTAMATE FORMATION AT GLN-23, AND AMIDATION
RP AT TRP-30.
RX PubMed=4063072; DOI=10.1515/bchm3.1985.366.2.723;
RA Siegert K., Morgan P., Mordue W.;
RT "Primary structures of locust adipokinetic hormones II.";
RL Biol. Chem. Hoppe-Seyler 366:723-727(1985).
RN [3]
RP PROTEIN SEQUENCE OF 23-30.
RX PubMed=3947348; DOI=10.1016/s0006-291x(86)80480-6;
RA Gaede G., Goldsworthy G.J., Schaffer M.H., Cook J.C., Rinehart K.L. Jr.;
RT "Sequence analyses of adipokinetic hormones II from corpora cardiaca of
RT Schistocerca nitans, Schistocerca gregaria, and Locusta migratoria by fast
RT atom bombardment mass spectrometry.";
RL Biochem. Biophys. Res. Commun. 134:723-730(1986).
RN [4]
RP PROTEIN SEQUENCE OF 34-61.
RX PubMed=2731552; DOI=10.1111/j.1432-1033.1989.tb14802.x;
RA Hietter H., Luu B., Goltzene F., Zachary D., Hoffmann J.A.,
RA van Dorsselaer A.;
RT "Isolation and structure of two novel 6-kDa dimeric peptides from the
RT corpora cardiaca of the insect Locusta migratoria. Molecular mass
RT determination by mass spectrometry.";
RL Eur. J. Biochem. 182:77-84(1989).
CC -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC causes release of diglycerides from the fat body and stimulation of
CC muscles to use these diglycerides as an energy source during energy-
CC demanding processes.
CC -!- SUBUNIT: Adipokinetic hormone precursor-related peptide (APRP) can form
CC three type of disulfide-bond dimers: p1 (alpha-alpha), p2 (alpha-beta),
CC and p3 (beta-beta).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR EMBL; X86800; CAA60495.1; -; mRNA.
DR PIR; B58652; AKLQL2.
DR AlphaFoldDB; P08379; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR002047; Adipokinetic_hormone_CS.
DR PROSITE; PS00256; AKH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Flight; Hormone; Neuropeptide; Pyrrolidone carboxylic acid;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:3947348,
FT ECO:0000269|PubMed:4063072"
FT CHAIN 23..61
FT /note="Adipokinetic prohormone type 2"
FT /id="PRO_0000000908"
FT PEPTIDE 23..30
FT /note="Adipokinetic hormone 2"
FT /id="PRO_0000000909"
FT PEPTIDE 34..61
FT /note="Adipokinetic hormone precursor-related peptide beta
FT chain"
FT /id="PRO_0000000910"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:4063072"
FT MOD_RES 30
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:4063072"
FT DISULFID 59
FT /note="Interchain"
SQ SEQUENCE 61 AA; 6588 MW; 3436B59C3712A046 CRC64;
MTQSCTLTLV LVVAVLAALA TAQLNFSAGW GRRYADPNAD PMAFLYRLIQ IEARKLAGCS
D
