ID   AKH2_SCHGR              Reviewed;          39 AA.
AC   P35808; P08378;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Adipokinetic prohormone type 2;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone 2;
DE     AltName: Full=Adipokinetic hormone II;
DE              Short=AKH-II;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone precursor-related peptide beta chain;
DE              Short=APRP-beta;
DE   Flags: Precursor;
OS   Schistocerca gregaria (Desert locust) (Gryllus gregarius).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX   NCBI_TaxID=7010;
RN   [1]
RP   PROTEIN SEQUENCE, AND PROTEOLYTIC PROCESSING.
RX   PubMed=1941082; DOI=10.1523/jneurosci.11-10-03246.1991;
RA   Hekimi S., Fischer-Lougheed J., O'Shea M.;
RT   "Regulation of neuropeptide stoichiometry in neurosecretory cells.";
RL   J. Neurosci. 11:3246-3256(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-8, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   TRP-8.
RX   PubMed=4063072; DOI=10.1515/bchm3.1985.366.2.723;
RA   Siegert K., Morgan P., Mordue W.;
RT   "Primary structures of locust adipokinetic hormones II.";
RL   Biol. Chem. Hoppe-Seyler 366:723-727(1985).
CC   -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC       causes release of diglycerides from the fat body and stimulation of
CC       muscles to use these diglycerides as an energy source during energy-
CC       demanding processes.
CC   -!- SUBUNIT: Adipokinetic hormone precursor-related peptide (APRP) can form
CC       three type of disulfide-bond dimers: p1 (alpha-alpha), p2 (alpha-beta),
CC       and p3 (beta-beta).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   AlphaFoldDB; P35808; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Flight; Hormone; Neuropeptide; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   CHAIN           1..39
FT                   /note="Adipokinetic prohormone type 2"
FT                   /id="PRO_0000000920"
FT   PEPTIDE         1..8
FT                   /note="Adipokinetic hormone 2"
FT                   /id="PRO_0000000921"
FT   PEPTIDE         12..39
FT                   /note="Adipokinetic hormone precursor-related peptide beta
FT                   chain"
FT                   /id="PRO_0000000922"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:4063072"
FT   MOD_RES         8
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:4063072"
FT   DISULFID        37
FT                   /note="Interchain"
SQ   SEQUENCE   39 AA;  4371 MW;  DB80C45CE57310C3 CRC64;
     QLNFSTGWGR RYADPNADPM AFLTKLIQIE ARKLSGCSN