AKH2_SCHNI
ID AKH2_SCHNI Reviewed; 61 AA.
AC P35807; P08378;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Adipokinetic prohormone type 2;
DE Contains:
DE RecName: Full=Adipokinetic hormone 2;
DE AltName: Full=Adipokinetic hormone II;
DE Short=AKH-II;
DE Contains:
DE RecName: Full=Adipokinetic hormone precursor-related peptide beta chain;
DE Short=APRP-beta;
DE Flags: Precursor;
OS Schistocerca nitens (Vagrant locust) (Gray bird grasshopper).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC Acridoidea; Acrididae; Cyrtacanthacridinae; Schistocerca.
OX NCBI_TaxID=7011;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=2294116; DOI=10.1016/s0021-9258(19)40256-1;
RA Noyes B.E., Schaffer M.H.;
RT "The structurally similar neuropeptides adipokinetic hormone I and II are
RT derived from similar, very small mRNAs.";
RL J. Biol. Chem. 265:483-489(1990).
RN [2]
RP PROTEIN SEQUENCE OF 23-30, PYROGLUTAMATE FORMATION AT GLN-23, AND AMIDATION
RP AT TRP-30.
RX PubMed=3947348; DOI=10.1016/s0006-291x(86)80480-6;
RA Gaede G., Goldsworthy G.J., Schaffer M.H., Cook J.C., Rinehart K.L. Jr.;
RT "Sequence analyses of adipokinetic hormones II from corpora cardiaca of
RT Schistocerca nitans, Schistocerca gregaria, and Locusta migratoria by fast
RT atom bombardment mass spectrometry.";
RL Biochem. Biophys. Res. Commun. 134:723-730(1986).
CC -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC causes release of diglycerides from the fat body and stimulation of
CC muscles to use these diglycerides as an energy source during energy-
CC demanding processes.
CC -!- SUBUNIT: Adipokinetic hormone precursor-related peptide (APRP) can form
CC three type of disulfide-bond dimers: p1 (alpha-alpha), p2 (alpha-beta),
CC and p3 (beta-beta).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR EMBL; L08775; AAA73930.1; -; Genomic_DNA.
DR EMBL; L08774; AAA73930.1; JOINED; Genomic_DNA.
DR EMBL; J05171; AAA73932.1; -; mRNA.
DR PIR; B34913; B34913.
DR AlphaFoldDB; P35807; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR002047; Adipokinetic_hormone_CS.
DR PROSITE; PS00256; AKH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Flight; Hormone; Neuropeptide; Pyrrolidone carboxylic acid;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:3947348"
FT CHAIN 23..61
FT /note="Adipokinetic prohormone type 2"
FT /id="PRO_0000000926"
FT PEPTIDE 23..30
FT /note="Adipokinetic hormone 2"
FT /evidence="ECO:0000269|PubMed:3947348"
FT /id="PRO_0000000927"
FT PEPTIDE 34..61
FT /note="Adipokinetic hormone precursor-related peptide beta
FT chain"
FT /id="PRO_0000000928"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:3947348"
FT MOD_RES 30
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:3947348"
FT DISULFID 59
FT /note="Interchain"
SQ SEQUENCE 61 AA; 6634 MW; 85BFA005436A9597 CRC64;
MRQGCALTLM LLVVVCAALS AAQLNFSTGW GRRYADPNAD PMAFLYKLIQ IEARKLAGCS
N
