AKH3_LOCMI
ID AKH3_LOCMI Reviewed; 77 AA.
AC P19872;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 3.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Adipokinetic prohormone type 3;
DE Contains:
DE RecName: Full=Adipokinetic hormone 3;
DE AltName: Full=Adipokinetic hormone III;
DE Short=AKH-III;
DE Contains:
DE RecName: Full=Adipokinetic hormone precursor-related peptide gamma chain;
DE Short=APRP-gamma;
DE Flags: Precursor;
OS Locusta migratoria (Migratory locust).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC Acridoidea; Acrididae; Oedipodinae; Locusta.
OX NCBI_TaxID=7004;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Corpora cardiaca;
RX PubMed=7559443; DOI=10.1074/jbc.270.39.23038;
RA Bogerd J., Kooiman F.P., Pijnenburg M.A.P., Hekking L.H., Oudejans R.C.,
RA Vander Horst D.J.;
RT "Molecular cloning of three distinct cDNAs, each encoding a different
RT adipokinetic hormone precursor, of the migratory locust, Locusta
RT migratoria. Differential expression of the distinct adipokinetic hormone
RT precursor genes during flight activity.";
RL J. Biol. Chem. 270:23038-23043(1995).
RN [2]
RP PROTEIN SEQUENCE OF 23-30, PYROGLUTAMATE FORMATION AT GLN-23, AND AMIDATION
RP AT TRP-30.
RC TISSUE=Corpora cardiaca;
RX PubMed=1997320; DOI=10.1111/j.1432-1033.1991.tb15713.x;
RA Oudejans R.C.H.M., Kooiman F.P., Heerma W., Versluis C., Slotboom A.J.,
RA Beenakkers A.M.T.;
RT "Isolation and structure elucidation of a novel adipokinetic hormone (Lom-
RT AKH-III) from the glandular lobes of the corpus cardiacum of the migratory
RT locust, Locusta migratoria.";
RL Eur. J. Biochem. 195:351-359(1991).
CC -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC causes release of diglycerides from the fat body and stimulation of
CC muscles to use these diglycerides as an energy source during energy-
CC demanding processes.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X86801; CAA60496.1; -; mRNA.
DR PIR; C58652; C58652.
DR AlphaFoldDB; P19872; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR002047; Adipokinetic_hormone_CS.
DR InterPro; IPR010475; AKH/RPCH_hormone.
DR Pfam; PF06377; Adipokin_hormo; 1.
DR PROSITE; PS00256; AKH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Flight; Hormone; Neuropeptide; Pyrrolidone carboxylic acid; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:1997320"
FT CHAIN 23..77
FT /note="Adipokinetic prohormone type 3"
FT /id="PRO_0000000911"
FT PEPTIDE 23..30
FT /note="Adipokinetic hormone 3"
FT /id="PRO_0000000912"
FT PEPTIDE 34..77
FT /note="Adipokinetic hormone precursor-related peptide gamma
FT chain"
FT /id="PRO_0000000913"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:1997320"
FT MOD_RES 30
FT /note="Tryptophan amide"
FT /evidence="ECO:0000269|PubMed:1997320"
SQ SEQUENCE 77 AA; 8024 MW; 78D761E7E33B4FC7 CRC64;
MQVRAVLVLA VVALVAVATS RAQLNFTPWW GKRALGAPAA GDCVSASPQA LLSILNAAQA
EVQKLIDCSR FTSEANS
