FIG1_YEAST
ID FIG1_YEAST Reviewed; 298 AA.
AC P38224; D6VQ40; Q70DD9; Q70DE0; Q70DE1; Q70DE3; Q70DE4; Q70DE5; Q70DE6;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Factor-induced gene 1 protein;
GN Name=FIG1; OrderedLocusNames=YBR040W; ORFNames=YBR0410;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS 1-MET--SER-5 DEL; VAL-153;
RP LEU-203; ILE-204; GLU-220; ILE-223; ASN-236 AND THR-241.
RC STRAIN=CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556,
RC CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12, and YIIc17;
RX PubMed=15087486; DOI=10.1093/nar/gkh529;
RA Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S.,
RA Souciet J.-L.;
RT "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and
RT implication of recombination in phylogeny.";
RL Nucleic Acids Res. 32:2069-2078(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; THR-293 AND SER-296, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ADR376;
RX PubMed=17330950; DOI=10.1021/pr060559j;
RA Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
RA Elias J.E., Gygi S.P.;
RT "Large-scale phosphorylation analysis of alpha-factor-arrested
RT Saccharomyces cerevisiae.";
RL J. Proteome Res. 6:1190-1197(2007).
CC -!- FUNCTION: Required for efficient mating.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: By mating pheromones.
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DR EMBL; AJ585600; CAE52120.1; -; Genomic_DNA.
DR EMBL; AJ585601; CAE52121.1; -; Genomic_DNA.
DR EMBL; AJ585602; CAE52122.1; -; Genomic_DNA.
DR EMBL; AJ585603; CAE52123.1; -; Genomic_DNA.
DR EMBL; AJ585604; CAE52124.1; -; Genomic_DNA.
DR EMBL; AJ585605; CAE52125.1; -; Genomic_DNA.
DR EMBL; AJ585606; CAE52126.1; -; Genomic_DNA.
DR EMBL; AJ585607; CAE52127.1; -; Genomic_DNA.
DR EMBL; AJ585608; CAE52128.1; -; Genomic_DNA.
DR EMBL; AJ585609; CAE52129.1; -; Genomic_DNA.
DR EMBL; AJ585610; CAE52130.1; -; Genomic_DNA.
DR EMBL; AJ585611; CAE52131.1; -; Genomic_DNA.
DR EMBL; AJ585612; CAE52132.1; -; Genomic_DNA.
DR EMBL; AJ585613; CAE52133.1; -; Genomic_DNA.
DR EMBL; AJ585614; CAE52134.1; -; Genomic_DNA.
DR EMBL; AJ585615; CAE52135.1; -; Genomic_DNA.
DR EMBL; AJ585616; CAE52136.1; -; Genomic_DNA.
DR EMBL; AJ585617; CAE52137.1; -; Genomic_DNA.
DR EMBL; AJ585618; CAE52138.1; -; Genomic_DNA.
DR EMBL; AJ585619; CAE52139.1; -; Genomic_DNA.
DR EMBL; Z35909; CAA84982.1; -; Genomic_DNA.
DR EMBL; AY557864; AAS56190.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07160.1; -; Genomic_DNA.
DR PIR; S45898; S45898.
DR RefSeq; NP_009596.1; NM_001178388.1.
DR AlphaFoldDB; P38224; -.
DR BioGRID; 32741; 145.
DR DIP; DIP-1347N; -.
DR IntAct; P38224; 1.
DR MINT; P38224; -.
DR STRING; 4932.YBR040W; -.
DR TCDB; 1.A.81.1.1; the low affinity ca(2+) channel (lacc) family.
DR iPTMnet; P38224; -.
DR PaxDb; P38224; -.
DR EnsemblFungi; YBR040W_mRNA; YBR040W; YBR040W.
DR GeneID; 852328; -.
DR KEGG; sce:YBR040W; -.
DR SGD; S000000244; FIG1.
DR VEuPathDB; FungiDB:YBR040W; -.
DR eggNOG; ENOG502QUDU; Eukaryota.
DR HOGENOM; CLU_075335_0_0_1; -.
DR InParanoid; P38224; -.
DR OMA; YFGICVN; -.
DR BioCyc; YEAST:G3O-29014-MON; -.
DR PRO; PR:P38224; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38224; protein.
DR GO; GO:0009277; C:fungal-type cell wall; IDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043332; C:mating projection tip; IDA:SGD.
DR GO; GO:0000753; P:cell morphogenesis involved in conjugation with cellular fusion; IMP:SGD.
DR GO; GO:0000747; P:conjugation with cellular fusion; IBA:GO_Central.
DR GO; GO:0000755; P:cytogamy; IMP:SGD.
DR InterPro; IPR033481; Dni1/Fig1.
DR InterPro; IPR016509; Fig1.
DR PANTHER; PTHR28092; PTHR28092; 1.
DR Pfam; PF12351; Fig1; 1.
DR PIRSF; PIRSF007138; FIG1; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..298
FT /note="Factor-induced gene 1 protein"
FT /id="PRO_0000087242"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 288
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17330950"
FT MOD_RES 293
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17330950"
FT MOD_RES 296
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17330950"
FT VARIANT 1..5
FT /note="Missing (in strain: CLIB 556 haplotype Ha1 and CLIB
FT 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 153
FT /note="L -> V (in strain: CLIB 413 haplotype Ha1)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 203
FT /note="I -> L (in strain: CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 204
FT /note="V -> I (in strain: K1)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 220
FT /note="A -> E (in strain: CLIB 413 haplotype Ha2)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 223
FT /note="R -> I (in strain: CLIB 630)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 236
FT /note="K -> N (in strain: CLIB 219)"
FT /evidence="ECO:0000269|PubMed:15087486"
FT VARIANT 241
FT /note="A -> T (in strain: CLIB 388 haplotype Ha2)"
FT /evidence="ECO:0000269|PubMed:15087486"
SQ SEQUENCE 298 AA; 33776 MW; 6C72CBA2E9C5A0D8 CRC64;
MVAISMIWFF TKRMPRIFAL AFNLISIFLL IFLLIGCYNP SNQSTFLVKY KFDDNSPFYT
IIEKSYEKSN TTLGLEEVII RSGYMGVCID NIPSQYSSYN NMTTFSNSIC YARKNLSSVP
LYRDLEIQLS NIASSSSKTQ SSVVLNILKL AQLTSVNVIH PYVLMATVIL TILMFLFILY
VTVPKLPFKL AVNKFLLLLS STIVLTWGIG AMWTHVGINA SYRLVPSSSM NIITVKKGKK
AAVMAWFSFA FLLLDSVVLW LIFLRDRKSL KDEIDNVPCA QNRYNNYSSD SSTLHSKV
