ID   FIGL1_XENTR             Reviewed;         656 AA.
AC   A4IHT0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Fidgetin-like protein 1;
DE            EC=3.6.4.-;
GN   Name=fignl1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in DNA double-strand break (DBS) repair via
CC       homologous recombination (HR). May regulate osteoblast proliferation
CC       and differentiation (By similarity). {ECO:0000250|UniProtKB:Q6PIW4}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Hexamer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PIW4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8BPY9}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q8BPY9}.
CC   -!- DOMAIN: The N-terminus is necessary for its recruitment to DNA damage
CC       sites. {ECO:0000250|UniProtKB:Q6PIW4}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; BC135671; AAI35672.1; -; mRNA.
DR   RefSeq; NP_001096311.1; NM_001102841.1.
DR   RefSeq; XP_012819639.1; XM_012964185.2.
DR   RefSeq; XP_012819640.1; XM_012964186.2.
DR   RefSeq; XP_012819641.1; XM_012964187.2.
DR   AlphaFoldDB; A4IHT0; -.
DR   SMR; A4IHT0; -.
DR   STRING; 8364.ENSXETP00000017156; -.
DR   PaxDb; A4IHT0; -.
DR   DNASU; 100124890; -.
DR   GeneID; 100124890; -.
DR   KEGG; xtr:100124890; -.
DR   CTD; 63979; -.
DR   Xenbase; XB-GENE-1000359; fignl1.
DR   eggNOG; KOG0740; Eukaryota.
DR   HOGENOM; CLU_000688_21_10_1; -.
DR   InParanoid; A4IHT0; -.
DR   OMA; FVIARCH; -.
DR   OrthoDB; 1176820at2759; -.
DR   PhylomeDB; A4IHT0; -.
DR   TreeFam; TF105013; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015704; Expressed in egg cell and 12 other tissues.
DR   ExpressionAtlas; A4IHT0; baseline and differential.
DR   GO; GO:0000228; C:nuclear chromosome; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; ISS:UniProtKB.
DR   GO; GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
DR   GO; GO:0008568; F:microtubule severing ATPase activity; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR   GO; GO:0046034; P:ATP metabolic process; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015415; Vps4_C.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF09336; Vps4_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Hydrolase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..656
FT                   /note="Fidgetin-like protein 1"
FT                   /id="PRO_0000302727"
FT   REGION          293..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         386
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PIW4"
FT   BINDING         426..431
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PIW4"
SQ   SEQUENCE   656 AA;  71909 MW;  46DA9048E497EF09 CRC64;
     MQVPESSLAH LSEWQRDAFV LSSGTCLPQQ KAEVYRAHLA QIQYAWANSE ISEASAVHLF
     KKYAEKYSAI IDSDKLEIGL NNYADSILTL AKCQRNESDK WQSSLTTNNV LKLKSVQDMA
     VAGRRTQLSK SSADASVRVG NGINTSGYSA GLGNNVLRNS GYTVPHAALS DCQMPGGSAN
     FLQKPKISAF TIANTTSVAN TSSNTLINNS ISMTSSLMQS NEDKDPASFS GHMFLPTTSV
     HSGKRKAYSA LGNESSDIKP NPLVQRQLTN KEATCESGFK TAKEQLWVDQ QKKYSNQPQR
     NPSPLYGGAK KSLGAARSRG LHGKFVPPVP RQEDVQDSNR KVYGQGNSEM NAPSDERLKN
     IEPKMIELIM SEIMDHGPPL NWDDIAGLEF AKTTIKEIVV WPMLRPDIFT GLRGPPKGIL
     LFGPPGTGKT LIGKCIACQS GATFFSISAS SLTSKWVGEG EKMVRALFTV ARCHQPAVIF
     IDEIDSLLSQ RGEGEHESSR RIKTEFLVQL DGATTSSDDR ILVVGATNRP QEIDEAARRR
     LVKRLYIPLP EASARKQIVV SLMAKEHCSL AEQEVEAIVL QADGFSGADM TQLCREAALG
     PIRSIQLMDI STITPEQVRP IAYIDFQSAF LVVRPSVSQK DLELYENWNK TFGCGR