FIGL2_HUMAN
ID FIGL2_HUMAN Reviewed; 653 AA.
AC A6NMB9;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Fidgetin-like protein 2 {ECO:0000305};
GN Name=FIGNL2 {ECO:0000312|HGNC:HGNC:13287};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR EMBL; AC068987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC156212; AAI56213.1; -; mRNA.
DR CCDS; CCDS86302.1; -.
DR RefSeq; NP_001013712.4; NM_001013690.4.
DR RefSeq; XP_005268927.1; XM_005268870.3.
DR AlphaFoldDB; A6NMB9; -.
DR SMR; A6NMB9; -.
DR BioGRID; 135217; 7.
DR iPTMnet; A6NMB9; -.
DR PhosphoSitePlus; A6NMB9; -.
DR BioMuta; FIGNL2; -.
DR EPD; A6NMB9; -.
DR MassIVE; A6NMB9; -.
DR PeptideAtlas; A6NMB9; -.
DR PRIDE; A6NMB9; -.
DR ProteomicsDB; 1529; -.
DR Antibodypedia; 78621; 7 antibodies from 4 providers.
DR DNASU; 401720; -.
DR Ensembl; ENST00000618634.3; ENSP00000491257.1; ENSG00000261308.4.
DR GeneID; 401720; -.
DR KEGG; hsa:401720; -.
DR MANE-Select; ENST00000618634.3; ENSP00000491257.1; NM_001384995.1; NP_001371924.1.
DR CTD; 401720; -.
DR GeneCards; FIGNL2; -.
DR HGNC; HGNC:13287; FIGNL2.
DR HPA; ENSG00000261308; Tissue enhanced (kidney, parathyroid gland).
DR neXtProt; NX_A6NMB9; -.
DR OpenTargets; ENSG00000261308; -.
DR PharmGKB; PA162388579; -.
DR VEuPathDB; HostDB:ENSG00000261308; -.
DR GeneTree; ENSGT00940000161971; -.
DR InParanoid; A6NMB9; -.
DR OMA; EQPKSPY; -.
DR OrthoDB; 1193464at2759; -.
DR PhylomeDB; A6NMB9; -.
DR PathwayCommons; A6NMB9; -.
DR SignaLink; A6NMB9; -.
DR BioGRID-ORCS; 401720; 5 hits in 205 CRISPR screens.
DR ChiTaRS; FIGNL2; human.
DR GenomeRNAi; 401720; -.
DR Pharos; A6NMB9; Tdark.
DR PRO; PR:A6NMB9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A6NMB9; protein.
DR Bgee; ENSG00000261308; Expressed in metanephros cortex and 69 other tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008568; F:microtubule severing ATPase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..653
FT /note="Fidgetin-like protein 2"
FT /id="PRO_0000343702"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 395
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 435..440
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT VARIANT 366
FT /note="T -> P (in dbSNP:rs303819)"
FT /id="VAR_044425"
SQ SEQUENCE 653 AA; 66603 MW; D84AD37DEFA9EB0C CRC64;
MHWTPEHAQP LNQWPEQHLD VSSTTPSPAH KLELPPGGRQ RCHYAWAHDD ISALTASNLL
KRYAEKYSGV LDSPYERPAL GGYSDASFLN GAKGDPEPWP GPEPPYPLAS LHEGLPGTKS
GGGGGSGALG GSPVLAGNLP EPLYAGNACG GPSAAPEYAA GYGGGYLAPG YCAQTGAALP
PPPPAALLQP PPPPGYGPSA PLYNYPAGGY AAQPGYGALP PPPGPPPAPY LTPGLPAPTP
LPAPAPPTAY GFPTAAPGAE SGLSLKRKAA DEGPEGRYRK YAYEPAKAPV ADGASYPAAD
NGECRGNGFR AKPPGAAEEA SGKYGGGVPL KVLGSPVYGP QLEPFEKFPE RAPAPRGGFA
VPSGETPKGV DPGALELVTS KMVDCGPPVQ WADVAGQGAL KAALEEELVW PLLRPPAYPG
SLRPPRTVLL FGPRGAGKAL LGRCLATQLG ATLLRLRGAT LAAPGAAEGA RLLQAAFAAA
RCRPPSVLLI SELEALLPAR DDGAAAGGAL QVPLLACLDG GCGAGADGVL VVGTTSRPAA
LDEATRRRFS LRFYVALPDS PARGQILQRA LAQQGCALSE RELAALVQGT QGFSGGELGQ
LCQQAAAGAG LPGLQRPLSY KDLEAALAKV GPRASAKELD SFVEWDKMYG SGH
