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FIL1L_MOUSE
ID   FIL1L_MOUSE             Reviewed;        1131 AA.
AC   Q6P6L0; B2ZAA3; B3GM33; Q05CK4; Q3UIY5; Q4G0B9;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Filamin A-interacting protein 1-like;
DE   AltName: Full=Protein down-regulated in ovarian cancer 1 homolog;
DE            Short=DOC-1;
GN   Name=Filip1l; Synonyms=Doc1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=C3H/HeJ;
RA   Revert-Ros F., Saadeddin A., Saus J.;
RT   "Molecular cloning of a novel variant of mouse downregulated in ovarian
RT   cancer 1 (DOC1) homolog.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Embryonic heart;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 223-1131 (ISOFORM 1).
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Colon, Embryo, and Limb;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-789, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic fibroblast;
RX   PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA   Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT   "Large scale localization of protein phosphorylation by use of electron
RT   capture dissociation mass spectrometry.";
RL   Mol. Cell. Proteomics 8:904-912(2009).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-789; THR-984; THR-992 AND
RP   SER-1050, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, and
RC   Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Acts as a regulator of the antiangiogenic activity on
CC       endothelial cells. When overexpressed in endothelial cells, leads to
CC       inhibition of cell proliferation and migration and an increase in
CC       apoptosis. Inhibits melanoma growth When expressed in tumor-associated
CC       vasculature (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.
CC       Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6P6L0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P6L0-2; Sequence=VSP_029208, VSP_029209;
CC       Name=3;
CC         IsoId=Q6P6L0-3; Sequence=VSP_029207;
CC   -!- SIMILARITY: Belongs to the FILIP1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH24523.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH24523.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC       Sequence=AAH62166.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=ACC91883.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; EU623548; ACC91883.1; ALT_INIT; mRNA.
DR   EMBL; EU704258; ACD92726.1; -; mRNA.
DR   EMBL; AK146705; BAE27371.1; -; mRNA.
DR   EMBL; BC024523; AAH24523.1; ALT_SEQ; mRNA.
DR   EMBL; BC062166; AAH62166.1; ALT_INIT; mRNA.
DR   EMBL; BC098507; AAH98507.1; -; mRNA.
DR   CCDS; CCDS37366.2; -. [Q6P6L0-1]
DR   CCDS; CCDS49877.1; -. [Q6P6L0-3]
DR   AlphaFoldDB; Q6P6L0; -.
DR   SMR; Q6P6L0; -.
DR   IntAct; Q6P6L0; 1.
DR   STRING; 10090.ENSMUSP00000124179; -.
DR   iPTMnet; Q6P6L0; -.
DR   PhosphoSitePlus; Q6P6L0; -.
DR   jPOST; Q6P6L0; -.
DR   MaxQB; Q6P6L0; -.
DR   PaxDb; Q6P6L0; -.
DR   PRIDE; Q6P6L0; -.
DR   ProteomicsDB; 266846; -. [Q6P6L0-1]
DR   ProteomicsDB; 266848; -. [Q6P6L0-3]
DR   Antibodypedia; 46504; 107 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000099667; ENSMUSP00000133252; ENSMUSG00000043336. [Q6P6L0-2]
DR   MGI; MGI:1925999; Filip1l.
DR   VEuPathDB; HostDB:ENSMUSG00000043336; -.
DR   eggNOG; KOG1103; Eukaryota.
DR   GeneTree; ENSGT00950000182852; -.
DR   HOGENOM; CLU_104016_0_0_1; -.
DR   InParanoid; Q6P6L0; -.
DR   ChiTaRS; Filip1l; mouse.
DR   PRO; PR:Q6P6L0; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; Q6P6L0; protein.
DR   Bgee; ENSMUSG00000043336; Expressed in ascending aorta and 173 other tissues.
DR   ExpressionAtlas; Q6P6L0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019131; Cortactin-binding_p2_N.
DR   Pfam; PF09727; CortBP2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Membrane; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..1131
FT                   /note="Filamin A-interacting protein 1-like"
FT                   /id="PRO_0000309471"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          139..583
FT                   /evidence="ECO:0000255"
FT   COILED          610..780
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         789
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19131326,
FT                   ECO:0007744|PubMed:21183079"
FT   MOD_RES         984
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         992
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         1050
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   VAR_SEQ         1..238
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_029207"
FT   VAR_SEQ         201
FT                   /note="L -> I (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029208"
FT   VAR_SEQ         202..1131
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_029209"
FT   CONFLICT        632
FT                   /note="N -> K (in Ref. 1; ACD92726 and 2; ACC91883)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        783
FT                   /note="L -> V (in Ref. 1; ACD92726 and 2; ACC91883)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1131 AA;  129772 MW;  765E51CBFEEF91CE CRC64;
     MRSRSSNAEG SAPKQIPRHS KFQDSIQDMK HRTHKKDPSC ESEGVLPRPV SEKSHTGKGH
     HTEDLSRDDL LFLLSILEGE LQARDEVIGI LRAEKIDLAL LEAQYGFVTP KKVLEALQRD
     AFQAKSAPWQ EDIYEKPMNE LDKVVEKHKE SHRRILEQLL MVERSHRQTI MEMEEEKRKH
     KEYMKKSDEF INLLEQECER LKKLIDQETA SQEKKEQEKE KRIKTLKEEL TKLKSFALMV
     VDEQQRLTAQ LALQRQKIQA LTTSAKETQG KLALAEARAQ EEEQKATRLE KELQTQTTEF
     HQNQDKIMAK LTNEDSQNRQ LRQKLAALSR QIDELEETNR SLRKAEEELQ DIKDKINKGE
     YGNSGIMDEV DELRKRVLDM EGKDEELIKM EEQCRDLNKR LEKETVQSKD FKLEVDKLSV
     RITALEKLED ALDKSKQECY SLKCNLEKEK MTTKQLSEEL ESLNARIKEL EAIESRLEKT
     EITLKDDLTK LKTLTVMLVD ERKTMSEKLK QTEDKLQSTT SQLQAEQNKV TTVTEKLIEE
     TKRALKSKTD AEEKMYSVTK ERDDLRNKLK AEEEKGHDLL SKVTILKNRL QSLEAIEKDF
     VKNKLNQDSS KSTAALHQEN NKIKELSQEV ENLKLKLKDM KAIEDDLMKT EDEYETLERR
     YANERDKAQF LSQELEHAKM ELAKYKLAEK TESSHEQWLF RRLQEEEAKS GHLSREVDAL
     KEKIHEYMAT EDLICHLQGD HSLLQKKLNQ QENRNRDLGR EIENLTKELE RYRHFSKSLR
     PSLNGRRISD PQVFSKEVQT EAADSEPPDY KSLIPLERAV INGQFYEENE DQDDDPNEEE
     SVLSFRCSQS SSLPMNRKLW IPWMKSKEGH PQNGKIQTKS NGNFVQPGDL VLSHTPGQPL
     HIKVTPDHIQ NTATLEITSP TTESPHSYTS TAVIPNCGTP KQRITILQNA SITPIKSKSS
     TESLMNLEQS MSPVTMATFA RAQTPESCGS VTPERTMSPI QVLAMTGSPS SPEQGCSPEP
     IEISAKHAIF RVSPDRQSSW QFQRSNSNSS SVITTEDNKI HIHLGSPYMQ AVAGPMRPAS
     PSAPLQDNRT QGLTNGALNK TTNKVTSSIT ITPTATPLPR QSQITVSNIY N
 
 
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