FILA2_MOUSE
ID FILA2_MOUSE Reviewed; 2362 AA.
AC Q2VIS4; Q8CB36;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Filaggrin-2;
DE Short=FLG-2;
DE AltName: Full=Intermediate filament-associated protein;
GN Name=Flg2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RA Listwan P., Rothnagel J.A.;
RT "FLG-2, a novel repetitive protein that is abundantly expressed in
RT mammalian epidermis and functionally related to filaggrin.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2047-2362.
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1198; SER-1204; SER-1205;
RP SER-1278; SER-1284; SER-1285; SER-1356; SER-1362; SER-1363; SER-1438;
RP SER-1439; SER-1510; SER-1516; SER-1517; SER-1590; SER-1596; SER-1597;
RP SER-1744; SER-1750; SER-1751; SER-1824; SER-1830; SER-1831; SER-1902;
RP SER-1908; SER-1909; SER-1980; SER-1986; SER-1987 AND SER-2104, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Essential for normal cell-cell adhesion in the cornified cell
CC layers. Important for proper integrity and mechanical strength of the
CC stratum corneum of the epidermis. {ECO:0000250|UniProtKB:Q5D862}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5D862}.
CC Cytoplasmic granule {ECO:0000250|UniProtKB:Q5D862}.
CC -!- PTM: Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form
CC is degraded by calpain-1/CAPN1 more quickly and into shorter peptides
CC than the intact protein. {ECO:0000250|UniProtKB:Q5D862}.
CC -!- PTM: May be processed by calpain-1/CAPN1.
CC {ECO:0000250|UniProtKB:Q5D862}.
CC -!- SIMILARITY: Belongs to the S100-fused protein family. {ECO:0000305}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the S-100 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29615.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DQ118292; AAZ99028.1; -; Genomic_DNA.
DR EMBL; AK036878; BAC29615.1; ALT_INIT; mRNA.
DR RefSeq; NP_001013826.1; NM_001013804.1.
DR AlphaFoldDB; Q2VIS4; -.
DR SMR; Q2VIS4; -.
DR BioGRID; 230864; 1.
DR STRING; 10090.ENSMUSP00000096482; -.
DR iPTMnet; Q2VIS4; -.
DR PhosphoSitePlus; Q2VIS4; -.
DR jPOST; Q2VIS4; -.
DR PaxDb; Q2VIS4; -.
DR PRIDE; Q2VIS4; -.
DR ProteomicsDB; 266849; -.
DR GeneID; 229574; -.
DR KEGG; mmu:229574; -.
DR UCSC; uc029unl.1; mouse.
DR CTD; 388698; -.
DR MGI; MGI:3645678; Flg2.
DR eggNOG; ENOG502QQH0; Eukaryota.
DR InParanoid; Q2VIS4; -.
DR OrthoDB; 1315634at2759; -.
DR PhylomeDB; Q2VIS4; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 229574; 2 hits in 51 CRISPR screens.
DR PRO; PR:Q2VIS4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q2VIS4; protein.
DR GO; GO:0001533; C:cornified envelope; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0036457; C:keratohyalin granule; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; ISS:UniProtKB.
DR GO; GO:0048730; P:epidermis morphogenesis; ISS:UniProtKB.
DR GO; GO:0061436; P:establishment of skin barrier; IBA:GO_Central.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW Calcium; Cytoplasm; Metal-binding; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..2362
FT /note="Filaggrin-2"
FT /id="PRO_0000331455"
FT DOMAIN 8..43
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 49..84
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REPEAT 261..308
FT /note="Filaggrin 1"
FT REPEAT 373..414
FT /note="Filaggrin 2"
FT REPEAT 555..607
FT /note="Filaggrin 3"
FT REPEAT 672..723
FT /note="Filaggrin 4"
FT REPEAT 880..927
FT /note="Filaggrin 5"
FT REPEAT 984..1035
FT /note="Filaggrin 6"
FT REPEAT 1165..1210
FT /note="Filaggrin 7"
FT REPEAT 1280..1334
FT /note="Filaggrin 8"
FT REPEAT 1474..1522
FT /note="Filaggrin 9"
FT REPEAT 1723..1756
FT /note="Filaggrin 10"
FT REPEAT 2016..2070
FT /note="Filaggrin 11"
FT REPEAT 2218..2259
FT /note="Filaggrin 12"
FT REGION 1..81
FT /note="S-100-like"
FT /evidence="ECO:0000250"
FT REGION 96..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..2109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1063
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1478..1507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1558..1587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1613..1627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1667..1683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1745..1769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1792..1821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1828..1843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1847..1863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1903..1919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1925..1977
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1981..1997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2003..2082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 64
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 68
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 73
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT MOD_RES 1198
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1204
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1205
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1278
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1284
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1285
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1356
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1362
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1363
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1438
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1439
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1510
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1516
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1517
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1590
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1596
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1597
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1744
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1750
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1751
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1824
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1830
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1831
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1902
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1908
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1909
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1980
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1986
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1987
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2104
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 2118
FT /note="N -> H (in Ref. 1; AAZ99028)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2362 AA; 251372 MW; F3FB473737052808 CRC64;
MAYLLRSVVT IIDVFYKYTK QDEECGTLSK DELKELLEKE FRPILKNPDD PDTVDVIMHM
LDRDHDRRLD FTEFILMIFK LALACNKVLG KEYCKASGSK KHRRGHQHQE EESETEEEEE
TPRQKSGFRF SSWSEGEEHG HSSGGSRGPA KHRRGSNSKR LERQDELSSS EESRKKHHGS
IFGHSWSSNK EKDGSRSEEL GEKGDKSYDS PSRESEEEYE SGYRLNHQGR EGHSGLSCGL
EKNKYELNYI QLRKGGEQKL GYNTSSSGNS KIQSHVYGFS NSSGCCRPKN ASSSCQASRS
QGQGNQSCRT QSNCQSGTSG GQGYGCVSEG QSSRCCQPKP RSCSQSSSQR GYGSKQCGQP
QNCGRQQRMG SSHSSCCGPY GSGATQSSGC GQQRMSSCGH SSSSHQKGCS SNGFSKGDQR
ASGSGHSSCC EQHGTNSSQS SGFKQHGHES GQSCCGQHGT ASSQSSGYSQ HRVGSGQSCH
YGQHGSSSGQ SSSSGRHGSG SGQSSSSRHN RSGSSQSSGL EEHGSSSHQS HSSGHHGSGS
RQSSGSEQHG AVSGQSSGSG KHETGPSQSS SSGHHGSGSQ QHGGGSGQST GFGEHESSSG
HSSSSGQHRS GSRHSSGSGK HESGRSQSSG SGHHGSGSQQ HGGGSGNSTG FGEHGSSSHP
LPSSGQNESS SGQSSRSERH GTGSGQSSGF GQHGSGSHQS SSSGHNEYGS GQTSSSWPHG
KGSGQESGYG EQESGHGQSS SSWQHGTGPG QSSSSEEEES RPGQSSSSWQ HGKGSGQESG
YGEQEAGHGQ SSSSWQHGTG AGNQSSGYGE HKSGPSHSSR SWHHGTGSGQ SLGFGQHGKG
SHQSESSGHY ESVSEPSSSS WQHGNGSGES YGYGEHESGH GQSSSAWNHG NESGQSNGYG
EHESGHGQSS SAWNHGNESG QSNGFGENES GRDQEGYQQR ESFHGQHRHP LSQHEQHSQF
GYGRSPRSPV HPESSEGEEH SVVPRRYSGY GHGQGQAGHQ QRESGYGQRG RPQGPSQDSS
RQPQAGHGQP SQSGYGRSPR RSQVHPEYSE GEAHSEVSQR HSGSSHCHCH CHGQARHQQR
ESVHGQRGRP QGPSQDSSRH PQAGPGQPSQ SGSRRSPRSQ PVHPESSEGE EHSVVPQRHS
GSGHGHGQGQ GQAGHQQRES VHGQQGRPQG PSQDSSRQPQ AGQGQPSQSG SGRSPRRSPV
HPESSEGEEH SVVPQRHSGS GHGHGQGQGQ GQAGHQQRES VHGQRSRPQG PFQDSSRQPQ
AGQGQPSQSG SGRSPRRSPV HPESSEGEEH SVVPQRHSGS GHGHGQGQGQ AGHQQRESVH
GQPVRPEVPT QDSSRQPQAG QGQPSQSGSG RSPRRSPVHP ESSEGEEHSV VPQRNSESCH
CHCHDQAGHQ QRESVHGQRG RPQGPSQDSS RHPQAGPGQP SQSGSRRSPR SSPVHPESSE
GEEHSVVPQR HSGSGHGHGQ GQGQAGHQQR ESVHGQRGRP QGPTQDSSRQ PQAGQGQPSQ
SGSGRSPRRS PVHPESSEGE EHSVVPQRHS GSGHGHGHGQ GQGQAGHQQR ESVHGQRGRP
QGPSQDSSRQ PQAGQGQPSQ SGSGRSPRRS PVHPESSEGE EHSVVPQRYS GSGHGHGQGQ
AGHQQRESVH GQRGRPQGPS QDSSRQPQAG QGQPSQSGSG RSPRRSPVHP ESSEGEEHSV
IPQRHSGSGH SHGQGQVHAE HQQRESVHGQ RGRPQGPSQD SSRQPQAGQG QPSLSGSGRS
PRRSPVHPES SEGEEHSVVP QRHSHSESGH GHGQGQGQAG HQQRESVHGQ RGRPQGPSQD
SSRQPQAGQG QPSQSGSGRS PGRSPVHPES SEGEEHSVVP QRHSESGHGH GQGQGQAGHQ
QRESVHGQRG RPQGPSQDSS RQPQAGQGQP SQSGSGRSPR RSPVHPESSE GEEHSVVPQR
HSGSGHGHGQ GQGQAGHQQR ESVHGQPVRP QGPSQDSSSQ PQASQGQPSQ SGSGRSPRRS
PVHPESSEGE EHSVVPQRHS GSGHGHGQGQ GQAGHQQRES LHGQRGRSQS PFHPSHSIHW
QSKCTISKKS SRLSGHYGRN HFQSTISGNQ YDSSQSSRHG SYGPQDYDYG QSGYGPSGRL
RSNSQSSIPF SSAHRATNME VLPCGQSFSP SDHVGTKANE QIGELVFKYR ESETGPDQSV
DYYNLTESNS TTRGHECSHG HSVVVPEHSD DSDFNYGHSY NGKQQICQSQ PTVQSCFDDS
QYILFQKHLE SPSFGNQSGF SPNERQLYTC NESIDSYHLS SDSNNRNQIY SSNNSFPNLY
CIGTEQCIYL PSATILGEGT EGQEPGYTQP GTICKYNQFL DGRKSRTRGN HETGKMKSGS
AYLDSNTPLY TYVQEQKSYY FE