ID   FILR1_METH6             Reviewed;         446 AA.
AC   G7WMP6;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Methanogenesis regulatory protein FilR1 {ECO:0000305};
GN   Name=filR1 {ECO:0000303|PubMed:24748383};
GN   OrderedLocusNames=Mhar_0445 {ECO:0000312|EMBL:AET63830.1};
OS   Methanosaeta harundinacea (strain 6Ac).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanotrichales; Methanotrichaceae; Methanothrix.
OX   NCBI_TaxID=1110509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6Ac;
RX   PubMed=22590603; DOI=10.1371/journal.pone.0036756;
RA   Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.;
RT   "The genome characteristics and predicted function of methyl-group
RT   oxidation pathway in the obligate aceticlastic methanogens, Methanosaeta
RT   spp.";
RL   PLoS ONE 7:E36756-E36756(2012).
RN   [2]
RP   FUNCTION, DNA-BINDING, INDUCTION, AND PHOSPHORYLATION.
RC   STRAIN=6Ac;
RX   PubMed=24748383; DOI=10.1371/journal.pone.0095502;
RA   Li J., Zheng X., Guo X., Qi L., Dong X.;
RT   "Characterization of an archaeal two-component system that regulates
RT   methanogenesis in Methanosaeta harundinacea.";
RL   PLoS ONE 9:E95502-E95502(2014).
CC   -!- FUNCTION: Member of the two-component regulatory system FilI/FilRs,
CC       which is involved in the regulation of methanogenesis. Regulates its
CC       own expression, expression of the filI-filR2 operon, and of genes
CC       involved in methanogenesis such as acs1, acs4 and mtrABC. Acts by
CC       binding to the promoters. {ECO:0000269|PubMed:24748383}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000269|PubMed:24748383}.
CC   -!- PTM: Phosphorylated by FilI. {ECO:0000269|PubMed:24748383}.
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DR   EMBL; CP003117; AET63830.1; -; Genomic_DNA.
DR   RefSeq; WP_014586015.1; NC_017527.1.
DR   AlphaFoldDB; G7WMP6; -.
DR   SMR; G7WMP6; -.
DR   STRING; 1110509.Mhar_0445; -.
DR   EnsemblBacteria; AET63830; AET63830; Mhar_0445.
DR   GeneID; 12509614; -.
DR   KEGG; mhi:Mhar_0445; -.
DR   PATRIC; fig|1110509.7.peg.497; -.
DR   HOGENOM; CLU_613410_0_0_2; -.
DR   OrthoDB; 76108at2157; -.
DR   Proteomes; UP000005877; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR013561; FilR1_middle_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF08350; DUF1724; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..446
FT                   /note="Methanogenesis regulatory protein FilR1"
FT                   /id="PRO_0000433371"
FT   DOMAIN          297..416
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         350
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   446 AA;  50141 MW;  853C19575A5C98BC CRC64;
     MDERDMVKRV KVFASSELKL NILLCLKYRE MDVNDLQGVL GGRNTTILHA IRDMTDDYLI
     SRGRQGYRLT NLGKIRGCVL ESLMGVLDDL EARPDFWLNH DISSIPPEML ERLSMLRRSE
     MVSTNPASPL EIHERLESLL STSKKISAIL PLLIFPKDSK VFTNALRRGS RVDLLMTEKI
     AGSLLDDGSI SAYEVERLLK FESFRLRLIG EDLKLALFVT ESFLYLGLYR HDGVYDVGTG
     AIYLGESAVA WGMELFEYYA QRSRELDEGD LTRVFRSSIQ PEAEAPPLAG EDPGAFDVMI
     VEDDLGHATL IRRIFEESSP RWRVHHASQL QDALRWIEES YGRPFLVVAD YLLPDGCGLD
     LAGKAERPLE VGFPLIILTG FGSEKIAAQA FKSGAMDYVV KEADSIQRLP EIAEEALLRW
     RELKRRAAGG EGHPSPQEGQ GLPLKV