FIM1C_BACO1
ID FIM1C_BACO1 Reviewed; 534 AA.
AC A7M4E1;
DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=Putative fimbrium tip subunit Fim1C;
DE Flags: Precursor;
GN ORFNames=BACOVA_04982 {ECO:0000312|EMBL:EDO09124.1};
OS Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 /
OS CCUG 4943 / NCTC 11153).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=411476 {ECO:0000312|Proteomes:UP000005475};
RN [1] {ECO:0000312|EMBL:EDO09124.1, ECO:0000312|Proteomes:UP000005475}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC
RC 11153 {ECO:0000312|Proteomes:UP000005475};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Bacteroides ovatus (ATCC 8483).";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 26-534, FUNCTION, SUBUNIT, AND
RP SUBCELLULAR LOCATION.
RX PubMed=27062925; DOI=10.1016/j.cell.2016.03.016;
RA Xu Q., Shoji M., Shibata S., Naito M., Sato K., Elsliger M.A., Grant J.C.,
RA Axelrod H.L., Chiu H.J., Farr C.L., Jaroszewski L., Knuth M.W.,
RA Deacon A.M., Godzik A., Lesley S.A., Curtis M.A., Nakayama K., Wilson I.A.;
RT "A distinct type of pilus from the human microbiome.";
RL Cell 165:690-703(2016).
CC -!- FUNCTION: Probably a component of the fimbrium tip. Fimbriae are
CC filamentous appendages on the cell surface that mediate cell adhesion
CC and biofilm formation. {ECO:0000305|PubMed:27062925}.
CC -!- SUBUNIT: May be part of the fimbrial tip.
CC {ECO:0000305|PubMed:27062925}.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000305|PubMed:27062925}. Cell
CC outer membrane {ECO:0000305}. Note=Probably synthesized as a
CC palmitoylated precursor. Efficient export to the outer membrane and
CC integration into fimbriae requires lipidation and subsequent
CC proteolytic removal of the lipidated propeptide. Probably part of the
CC fimbrium tip. {ECO:0000305|PubMed:27062925}.
CC -!- SIMILARITY: Belongs to the bacteroidetes fimbrillin superfamily. Mfa-
CC like family. {ECO:0000305}.
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DR EMBL; AAXF02000054; EDO09124.1; -; Genomic_DNA.
DR RefSeq; WP_004301586.1; NZ_DS264584.1.
DR PDB; 4EPS; X-ray; 1.85 A; A=26-534.
DR PDBsum; 4EPS; -.
DR AlphaFoldDB; A7M4E1; -.
DR SMR; A7M4E1; -.
DR STRING; 411476.BACOVA_04982; -.
DR EnsemblBacteria; EDO09124; EDO09124; BACOVA_04982.
DR GeneID; 29452115; -.
DR eggNOG; ENOG5033AY2; Bacteria.
DR HOGENOM; CLU_033781_0_0_10; -.
DR Proteomes; UP000005475; Unassembled WGS sequence.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.2620; -; 1.
DR InterPro; IPR025049; Mfa-like_1.
DR InterPro; IPR042278; Mfa-like_1_N.
DR Pfam; PF13149; Mfa_like_1; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Fimbrium; Lipoprotein; Membrane;
KW Palmitate; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT PROPEP 22..54
FT /evidence="ECO:0000255"
FT /id="PRO_0000436735"
FT CHAIN 55..534
FT /note="Putative fimbrium tip subunit Fim1C"
FT /id="PRO_5002712130"
FT LIPID 22
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT STRAND 38..43
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 69..76
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 84..91
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 93..99
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 105..107
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 111..117
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 128..131
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 135..139
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 150..154
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 167..169
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 172..181
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 183..189
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 192..198
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 211..214
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 219..224
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 227..229
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 230..232
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 234..236
FT /evidence="ECO:0007829|PDB:4EPS"
FT TURN 237..240
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 241..246
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 253..258
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 261..266
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 275..280
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 285..291
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 297..299
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 317..325
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 329..332
FT /evidence="ECO:0007829|PDB:4EPS"
FT TURN 333..335
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 343..345
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 347..351
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 357..363
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 366..368
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 378..383
FT /evidence="ECO:0007829|PDB:4EPS"
FT TURN 386..390
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 394..398
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 400..402
FT /evidence="ECO:0007829|PDB:4EPS"
FT TURN 404..406
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 407..409
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 413..427
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 432..443
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 458..462
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 470..474
FT /evidence="ECO:0007829|PDB:4EPS"
FT HELIX 476..482
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 493..498
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 500..509
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 514..521
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 526..528
FT /evidence="ECO:0007829|PDB:4EPS"
FT STRAND 531..534
FT /evidence="ECO:0007829|PDB:4EPS"
SQ SEQUENCE 534 AA; 59661 MW; 9C4D59EF0D4D00B7 CRC64;
MKQYKLMQVA LLAILLFGWA GCSQNEEEVP GNVRNGIVLN VTDTGIISNE PSTRTEDTGF
VTTFTQGDQI GLFAVKDGAI LDEINNMPFT FNGSSWSGKP ILYDDRLVGV NFYAYYPYQS
EMTGKTDLIG DDFFAPLAAG WELTTEQSDQ KAYAKQDLMT SNATALIGEN GNYSLSFQLT
HRMSLVVVKL PSTRYIFTDA EGVAMPEETP YVAMSVDVAF YLDNVEEGTK ISPYYDAKKD
EYRLLRKPSS ENQIIGHYND KQCTLDTAEK MKEGKYKRFV VDGGYKEVTH HLQVGDYYYA
DGSVVSGNEA EPAKDNCIGI VCWVGNPMPS VLYKDVAGTP YTATNDALLR SHPNCVHGLV
MSLYTETGKF SPALTQSIHD WFMTTSFTSS YVSVTGYYDA NENNKNKPLR FLGYNNSEVL
DLYYDTFKTD FECFQYQDDC ESSFPSPSIT TGWYVPSSGE LVALQDKDNS LESKLNTKLI
KVSDKTMDIS ATYWSSTERN NKNMYIVTYS KTAGSAGTGG VKTNTYTYRF FLGF
