FIMA1_ECOLX
ID FIMA1_ECOLX Reviewed; 184 AA.
AC Q47223; P94764;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Type-1 fimbrial protein, A chain {ECO:0000250|UniProtKB:P04128};
DE AltName: Full=Type-1A pilin {ECO:0000250|UniProtKB:P04128};
DE Flags: Precursor;
GN Name=fimA {ECO:0000312|EMBL:AAG24825.1};
OS Escherichia coli.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAA85727.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-33, AND
RP VARIABILITY.
RC STRAIN=O2:K1:H+ / MT78 {ECO:0000312|EMBL:CAA85727.1};
RX PubMed=8636962; DOI=10.1099/00222615-44-6-444;
RA Marc D., Dho-Moulin M.;
RT "Analysis of the fim cluster of an avian O2 strain of Escherichia coli:
RT serogroup-specific sites within fimA and nucleotide sequence of fimI.";
RL J. Med. Microbiol. 44:444-452(1996).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAG24825.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=LF82 / AIEC {ECO:0000312|EMBL:AAG24825.1};
RX PubMed=11251843; DOI=10.1111/j.1365-2958.2001.02315.x;
RA Boudeau J., Barnich N., Darfeuille-Michaud A.;
RT "Type 1 pili-mediated adherence of Escherichia coli strain LF82 isolated
RT from Crohn's disease is involved in bacterial invasion of intestinal
RT epithelial cells.";
RL Mol. Microbiol. 39:1272-1284(2001).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAO84635.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIABILITY.
RC STRAIN=21 / APEC {ECO:0000312|EMBL:AAO84635.1};
RX PubMed=12657207; DOI=10.1051/vetres:2002062;
RA Vandemaele F., Vandekerchove D., Vereecken M., Derijcke J., Dho-Moulin M.,
RA Goddeeris B.M.;
RT "Sequence analysis demonstrates the conservation of fimH and variability of
RT fimA throughout avian pathogenic Escherichia coli (APEC).";
RL Vet. Res. 34:153-163(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 24-31; 39-63 AND
RP 69-180.
RC STRAIN=K1 / RS218 / O18:K1:H7;
RX PubMed=20347420; DOI=10.1016/j.molcel.2010.02.015;
RA Sukumaran S.K., Fu N.Y., Tin C.B., Wan K.F., Lee S.S., Yu V.C.;
RT "A soluble form of the pilus protein FimA targets the VDAC-hexokinase
RT complex at mitochondria to suppress host cell apoptosis.";
RL Mol. Cell 37:768-783(2010).
CC -!- FUNCTION: Fimbriae (also called pili), polar filaments radiating from
CC the surface of the bacterium to a length of 0.5-1.5 micrometers and
CC numbering 100-300 per cell, enable bacteria to colonize the epithelium
CC of specific host organs. {ECO:0000250|UniProtKB:P04128,
CC ECO:0000269|PubMed:11251843}.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250|UniProtKB:P04128}.
CC -!- MISCELLANEOUS: The fimA gene is highly variable between different
CC strains of E.coli. {ECO:0000269|PubMed:12657207,
CC ECO:0000269|PubMed:8636962}.
CC -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000255}.
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DR EMBL; Z37500; CAA85727.1; -; Genomic_DNA.
DR EMBL; AF286465; AAG24825.1; -; Genomic_DNA.
DR EMBL; AF490877; AAO84635.1; -; Genomic_DNA.
DR EMBL; FN643152; CBI71394.1; -; Genomic_DNA.
DR PIR; S53065; S53065.
DR RefSeq; WP_000695580.1; NZ_VTAJ01000146.1.
DR AlphaFoldDB; Q47223; -.
DR SMR; Q47223; -.
DR STRING; 585034.ECIAI1_4530; -.
DR PATRIC; fig|562.10854.peg.1302; -.
DR OMA; QLNDCDS; -.
DR PHI-base; PHI:7205; -.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.1090; -; 1.
DR InterPro; IPR000259; Adhesion_dom_fimbrial.
DR InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR Pfam; PF00419; Fimbrial; 1.
DR SUPFAM; SSF49401; SSF49401; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Fimbrium; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:20347420,
FT ECO:0000269|PubMed:8636962"
FT CHAIN 24..184
FT /note="Type-1 fimbrial protein, A chain"
FT /evidence="ECO:0000269|PubMed:20347420"
FT /id="PRO_0000391700"
FT DISULFID 46..86
FT /evidence="ECO:0000250|UniProtKB:P04127"
SQ SEQUENCE 184 AA; 18553 MW; 26063D1B4267D08C CRC64;
MKIKTLAIVV LSALSLSSTA ALADTTPTTV NGGTVHFKGE VVNAACAVDA GSVDQTVQLG
QVRTATLKQA GATSSAVGFN IQLNDCDTTV ATKAAVAFLG TAIDSTHPKV LALQSSAAGS
ATNVGVQILD RTGNELTLDG ATFSAETTLN NGTNTIPFQA RYFATGAATP GAANADATFK
VQYQ
