FIMB2_ARATH
ID FIMB2_ARATH Reviewed; 654 AA.
AC O50064; O49971; Q67XH3;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=Fimbrin-2 {ECO:0000305};
DE Short=AtFIM2;
DE AltName: Full=Fimbrin2 {ECO:0000305};
GN Name=FIM2 {ECO:0000305};
GN OrderedLocusNames=At5g48460 {ECO:0000312|Araport:AT5G48460};
GN ORFNames=MJE7.9 {ECO:0000312|EMBL:BAA96966.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAB97847.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Christensen H.E.M., Mathur J., Chua N.H.;
RT "Arabidopsis Fimbrin.";
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 203-654.
RX PubMed=9484459; DOI=10.1023/a:1005884112192;
RA McCurdy D.W., Kim M.;
RT "Molecular cloning of a novel fimbrin-like cDNA from Arabidopsis
RT thaliana.";
RL Plant Mol. Biol. 36:23-31(1998).
CC -!- FUNCTION: Cross-links actin filaments (F-actin). Stabilizes and
CC prevents F-actin depolymerization mediated by profilin. May regulate
CC actin cytoarchitecture, cell cycle, cell division, cell elongation and
CC cytoplasmic tractus. {ECO:0000250|UniProtKB:Q7G188}.
CC -!- SUBUNIT: Interacts with F-actin. {ECO:0000250|UniProtKB:Q7G188}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q7G188}.
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DR EMBL; AF042669; AAB97844.1; -; mRNA.
DR EMBL; AF042671; AAB97847.1; -; Genomic_DNA.
DR EMBL; AB020745; BAA96966.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95673.1; -; Genomic_DNA.
DR EMBL; AK176846; BAD44609.1; -; mRNA.
DR EMBL; U77673; AAC49919.1; -; mRNA.
DR RefSeq; NP_199657.1; NM_124221.3.
DR AlphaFoldDB; O50064; -.
DR SMR; O50064; -.
DR STRING; 3702.AT5G48460.1; -.
DR iPTMnet; O50064; -.
DR PaxDb; O50064; -.
DR PRIDE; O50064; -.
DR ProteomicsDB; 230578; -.
DR EnsemblPlants; AT5G48460.1; AT5G48460.1; AT5G48460.
DR GeneID; 834901; -.
DR Gramene; AT5G48460.1; AT5G48460.1; AT5G48460.
DR KEGG; ath:AT5G48460; -.
DR Araport; AT5G48460; -.
DR TAIR; locus:2166096; AT5G48460.
DR eggNOG; KOG0046; Eukaryota.
DR HOGENOM; CLU_015284_3_1_1; -.
DR InParanoid; O50064; -.
DR OMA; DAEMVRW; -.
DR OrthoDB; 312506at2759; -.
DR PhylomeDB; O50064; -.
DR PRO; PR:O50064; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; O50064; baseline and differential.
DR Genevisible; O50064; AT.
DR GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR GO; GO:0032432; C:actin filament bundle; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0051017; P:actin filament bundle assembly; IDA:TAIR.
DR GO; GO:0051639; P:actin filament network formation; IBA:GO_Central.
DR CDD; cd00014; CH; 4.
DR Gene3D; 1.10.418.10; -; 4.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961; PTHR19961; 1.
DR Pfam; PF00307; CH; 4.
DR SMART; SM00033; CH; 4.
DR SUPFAM; SSF47473; SSF47473; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 4.
PE 2: Evidence at transcript level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT CHAIN 1..654
FT /note="Fimbrin-2"
FT /id="PRO_0000430598"
FT DOMAIN 124..241
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 269..372
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 394..500
FT /note="Calponin-homology (CH) 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 515..623
FT /note="Calponin-homology (CH) 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REGION 124..372
FT /note="Actin-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00300"
FT REGION 394..623
FT /note="Actin-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00300"
FT CONFLICT 71
FT /note="N -> K (in Ref. 4; BAD44609)"
SQ SEQUENCE 654 AA; 73665 MW; 85356BE2C8B9E278 CRC64;
MSGFVGILVS DPWLQNQFTQ VELRSLKSHF TSMKRESGKL TVSDLASRMG KSKVVGDQNL
SNEERATLIQ NFHPNLNDEV DFEFYLRIYL NLQAHVNAII GSGVKNSSAF LKAATTTLLH
TISDSEKSSY VAHINNYLSG DEFLNKCLPI NPSSNDLFEV AKDGVLLCKL INVAVPGTID
ERAINTKSML NPWERNENHT LCLNSAKAIG CTVVNIGTQD IIEGRRHLVL GVISQIIKIQ
LLADLNLKKT PQLVELVGDS KDVEELMSLP PEKILLRWMN FQLRKTEYKK TVTNFSSDVK
DAEAYTNLLN VLAPEHKNPS HLAVKSSFER AKLVLEHADK MGCRRYLTAK DIVEGSPNLN
LAFVAHIFQH RNGLSTQTKQ ISFLENLADD IQISREEKAF RFWINSFDGS VYINNVFEDL
RDGWILLQTL DKVSPGIVNW KVSSKPPIKL PFKKVENCNQ VVKLGKQLKF SLVNIAGNDI
VQGNKKLILA YLWQLMRYNI LQLLKNLRLH SNGKEITDAD ILEWANAKVR NNGCKTRMYS
FRDKSLSDGV FFLELLSSVQ PRSVNWSLVT NGVTDEEKKM NATYVISIAR KLGCSIFLLP
EDIIEVNQKM MLTLTASIMY WTLKQPLHLN KPIGSPDSHN GSLLDDSTSD SSIE
