ID   FIMB_ECO57              Reviewed;         200 AA.
AC   P0ADH6; P04742; Q47219;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Type 1 fimbriae regulatory protein FimB;
GN   Name=fimB; OrderedLocusNames=Z5910, ECs5271;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: FimB is one of the 2 regulatory proteins which control the
CC       phase variation of type 1 fimbriae in E.coli. These proteins mediate
CC       the periodic inversion of a 300bp DNA segment that harbors the promoter
CC       for the fimbrial structural gene, fimA. FimB switches fimA on (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG59494.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38694.1; -; Genomic_DNA.
DR   PIR; B86129; B86129.
DR   PIR; G91287; G91287.
DR   RefSeq; NP_313298.1; NC_002695.1.
DR   RefSeq; WP_000790583.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ADH6; -.
DR   SMR; P0ADH6; -.
DR   STRING; 155864.EDL933_5647; -.
DR   EnsemblBacteria; AAG59494; AAG59494; Z5910.
DR   EnsemblBacteria; BAB38694; BAB38694; ECs_5271.
DR   GeneID; 66671805; -.
DR   GeneID; 913695; -.
DR   KEGG; ece:Z5910; -.
DR   KEGG; ecs:ECs_5271; -.
DR   PATRIC; fig|386585.9.peg.5507; -.
DR   eggNOG; COG0582; Bacteria.
DR   HOGENOM; CLU_027562_39_0_6; -.
DR   OMA; KRWLAIR; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; Fimbrium biogenesis;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..200
FT                   /note="Type 1 fimbriae regulatory protein FimB"
FT                   /id="PRO_0000197540"
FT   DOMAIN          8..189
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        47
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        141
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        144
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        167
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        176
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   200 AA;  22993 MW;  36BFC656C68837C7 CRC64;
     MKNKADNKKR NFLTHSEIES LLKAANTGPH AARNYCLTLL CFIHGFRASE ICRLRISDID
     LKAKCIYIHR LKKGFSTTHP LLNKEVQALK NWLSIRTSYP HAESEWVFLS RKGNPLSRQQ
     FYHIISTSGG NAGLSLEIHP HMLRHSCGFA LANMGIDTRL IQDYLGHRNI RHTVWYTASN
     AGRFYGIWDR ARGRQRHAVL