FIMC_BORPE
ID FIMC_BORPE Reviewed; 873 AA.
AC P33410;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Outer membrane usher protein FimC;
DE Flags: Precursor;
GN Name=fimC; Synonyms=fhaA; OrderedLocusNames=BP1882;
OS Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=257313;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Wellcome 28;
RX PubMed=1360139; DOI=10.1111/j.1365-2958.1992.tb01443.x;
RA Willems R.J.L., van der Heide H.G.J., Mooi F.R.;
RT "Characterization of a Bordetella pertussis fimbrial gene cluster which is
RT located directly downstream of the filamentous haemagglutinin gene.";
RL Mol. Microbiol. 6:2661-2671(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX PubMed=1354611; DOI=10.1002/j.1460-2075.1992.tb05394.x;
RA Locht C., Geoffroy M.C., Renauld G.;
RT "Common accessory genes for the Bordetella pertussis filamentous
RT hemagglutinin and fimbriae share sequence similarities with the papC and
RT papD gene families.";
RL EMBO J. 11:3175-3183(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
CC -!- FUNCTION: Probable porin-like protein necessary for the assembly of a
CC pilin-type protein.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
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DR EMBL; X64876; CAA46090.1; -; Genomic_DNA.
DR EMBL; X66729; CAA47266.1; -; Genomic_DNA.
DR EMBL; BX640416; CAE42165.1; -; Genomic_DNA.
DR PIR; S25193; S25193.
DR RefSeq; NP_880573.1; NC_002929.2.
DR RefSeq; WP_010930612.1; NZ_CP039022.1.
DR AlphaFoldDB; P33410; -.
DR SMR; P33410; -.
DR STRING; 257313.BP1882; -.
DR TCDB; 1.B.11.3.1; the outer membrane fimbrial usher porin (fup) family.
DR KEGG; bpe:BP1882; -.
DR PATRIC; fig|257313.5.peg.2020; -.
DR eggNOG; COG3188; Bacteria.
DR HOGENOM; CLU_009120_1_0_4; -.
DR OMA; FYLSGRV; -.
DR Proteomes; UP000002676; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR Gene3D; 2.60.40.2070; -; 1.
DR Gene3D; 2.60.40.2610; -; 1.
DR Gene3D; 3.10.20.410; -; 1.
DR InterPro; IPR000015; Fimb_usher.
DR InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR InterPro; IPR042186; FimD_plug_dom.
DR InterPro; IPR025949; PapC-like_C.
DR InterPro; IPR043142; PapC-like_C_sf.
DR InterPro; IPR025885; PapC_N.
DR InterPro; IPR037224; PapC_N_sf.
DR PANTHER; PTHR30451; PTHR30451; 1.
DR Pfam; PF13953; PapC_C; 1.
DR Pfam; PF13954; PapC_N; 1.
DR Pfam; PF00577; Usher; 1.
DR SUPFAM; SSF141729; SSF141729; 1.
DR PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Disulfide bond; Fimbrium biogenesis; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane beta strand;
KW Transport.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..873
FT /note="Outer membrane usher protein FimC"
FT /id="PRO_0000009311"
FT DISULFID 815..838
FT /evidence="ECO:0000255"
FT CONFLICT 744
FT /note="G -> A (in Ref. 2; CAA47266)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 873 AA; 93369 MW; ACB8D8078388CB22 CRC64;
MKQIPLILAM SLAFAAAAKG ESAPDMQAAV NFDSAMLWGG ANGADLSRFN YSNALRPGNY
IVDIYANNYP LIRQQVRFVA AQTSGQGLKT APAVACFTYG QLEAMQVRLR ALDPALVADL
KSSGRCEVLG KLFPDSRESF DFGENRLEVS IPQAYTINRF RRDISPDEWD SGITAFRLGY
QYNYADYIGG LRAGRRLDLN LYSGFNFKGW YLRNSSTLGW GQGRFTRRSQ RTSLQTDIPS
WRARLVFGDV FSSGEYFAPY SMRGMLVGSD TAMLPYSERL YRPTIRGVAR TRANVKVYQA
GVLVFQDAVP PGPFAIDDYS PASYGGDLRV VVTEANGAVQ TFTVPYASAV RLILPGQTQW
SFSAGRYRNY RNDGQDRPWV TQLTGRHGVA DGVNLYGGLL IAQAYQAGLA GLSWNTPWGA
MAADATLSRS QLSTTGNANG SSLRFSYSKT LSGTNTAIRL ATLRYSSSGF WNFADAVNAG
PVETNGRNGR FGLYSLLGRE RPRGDFSVTL SQPLGGYGSL YVSALRRTYW GSSRVDQQTQ
LGYSTQVGRV GVNLDVSRTE NRRSTEHQVM LNLSIPLYGA TSSGVVTGSL ARTGSAPVQQ
SVNYSGMSGE RDQYTYGLGV QRAGTSAQYA LNGSWSGTYG EVSGQLTHGR SYSQYQINGS
GGLVAHAGGV TFGQYQAGTI GLIQAEAAAG AKVVNTRNAA VDRSGYGLVS LTPYSLNEVE
LSPQDLPLDV QLESTVEQVI PRAGAVVALR FPTRHDVAAM LVAEPGSEGA LVFGTEVRDG
AGKVVGVAGQ GASALVRGVS ASGTLEVTRA DGSICRATYD LKSAGQAVHG LPRIALACAP
QGGGERGARA AGQAVAQPSA ISISGKDHEP DIR
