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FIME_ECOLI
ID   FIME_ECOLI              Reviewed;         198 AA.
AC   P0ADH7; P04741; Q2M600;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Type 1 fimbriae regulatory protein FimE;
GN   Name=fimE; OrderedLocusNames=b4313, JW4276;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2874022; DOI=10.1002/j.1460-2075.1986.tb04372.x;
RA   Klemm P.;
RT   "Two regulatory fim genes, fimB and fimE, control the phase variation of
RT   type 1 fimbriae in Escherichia coli.";
RL   EMBO J. 5:1389-1393(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: FimE is one of the 2 regulatory proteins which control the
CC       phase variation of type 1 fimbriae in E.coli. These proteins mediate
CC       the periodic inversion of a 300bp DNA segment that harbors the promoter
CC       for the fimbrial structural gene, fimA. FimE switches fimA off.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; X03923; CAA27561.1; -; Genomic_DNA.
DR   EMBL; U14003; AAA97209.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77269.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78306.1; -; Genomic_DNA.
DR   PIR; B25111; RGECFE.
DR   RefSeq; NP_418733.1; NC_000913.3.
DR   RefSeq; WP_000044711.1; NZ_STEB01000025.1.
DR   AlphaFoldDB; P0ADH7; -.
DR   SMR; P0ADH7; -.
DR   BioGRID; 4259379; 56.
DR   IntAct; P0ADH7; 1.
DR   STRING; 511145.b4313; -.
DR   PaxDb; P0ADH7; -.
DR   PRIDE; P0ADH7; -.
DR   EnsemblBacteria; AAC77269; AAC77269; b4313.
DR   EnsemblBacteria; BAE78306; BAE78306; BAE78306.
DR   GeneID; 66671804; -.
DR   GeneID; 948836; -.
DR   KEGG; ecj:JW4276; -.
DR   KEGG; eco:b4313; -.
DR   PATRIC; fig|1411691.4.peg.2379; -.
DR   EchoBASE; EB0308; -.
DR   eggNOG; COG4974; Bacteria.
DR   HOGENOM; CLU_027562_39_0_6; -.
DR   InParanoid; P0ADH7; -.
DR   OMA; KYLGHQT; -.
DR   PhylomeDB; P0ADH7; -.
DR   BioCyc; EcoCyc:EG10312-MON; -.
DR   PRO; PR:P0ADH7; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IMP:EcoCyc.
DR   GO; GO:0006310; P:DNA recombination; IMP:EcoCyc.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; Fimbrium biogenesis;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..198
FT                   /note="Type 1 fimbriae regulatory protein FimE"
FT                   /id="PRO_0000197541"
FT   DOMAIN          2..184
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        41
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        66
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        136
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        139
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        162
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        171
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   198 AA;  23116 MW;  A33139B0378CB37D CRC64;
     MSKRRYLTGK EVQAMMQAVC YGATGARDYC LILLAYRHGM RISELLDLHY QDLDLNEGRI
     NIRRLKNGFS TVHPLRFDER EAVERWTQER ANWKGADRTD AIFISRRGSR LSRQQAYRII
     RDAGIEAGTV TQTHPHMLRH ACGYELAERG ADTRLIQDYL GHRNIRHTVR YTASNAARFA
     GLWERNNLIN EKLKREEV
 
 
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