FIMP_HUMAN
ID FIMP_HUMAN Reviewed; 132 AA.
AC Q96LL3; Q494R8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Fertilization-influencing membrane protein {ECO:0000303|PubMed:32295885};
GN Name=FIMP {ECO:0000303|PubMed:32295885};
GN Synonyms=C16orf92 {ECO:0000312|HGNC:HGNC:26346};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=32295885; DOI=10.1073/pnas.1917060117;
RA Fujihara Y., Lu Y., Noda T., Oji A., Larasati T., Kojima-Kita K., Yu Z.,
RA Matzuk R.M., Matzuk M.M., Ikawa M.;
RT "Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail
RT to fuse with oocytes in mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 117:9393-9400(2020).
CC -!- FUNCTION: May play a role in sperm-oocyte fusion during fertilization.
CC {ECO:0000250|UniProtKB:E9Q9R3}.
CC -!- INTERACTION:
CC Q96LL3; Q07325: CXCL9; NbExp=3; IntAct=EBI-12887376, EBI-3911467;
CC Q96LL3; Q7Z4F1: LRP10; NbExp=3; IntAct=EBI-12887376, EBI-2830349;
CC Q96LL3; Q96S97: MYADM; NbExp=3; IntAct=EBI-12887376, EBI-13301517;
CC Q96LL3; P42857: NSG1; NbExp=3; IntAct=EBI-12887376, EBI-6380741;
CC Q96LL3; P0DJD7: PGA4; NbExp=3; IntAct=EBI-12887376, EBI-12957629;
CC Q96LL3; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-12887376, EBI-11721828;
CC Q96LL3; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-12887376, EBI-10192441;
CC Q96LL3; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-12887376, EBI-8652744;
CC Q96LL3; P02808: STATH; NbExp=3; IntAct=EBI-12887376, EBI-738687;
CC Q96LL3; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-12887376, EBI-11722971;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E9Q9R3};
CC Single-pass type I membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96LL3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96LL3-2; Sequence=VSP_031783;
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:32295885}.
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DR EMBL; AK058133; BAB71678.1; -; mRNA.
DR EMBL; CH471238; EAW79941.1; -; Genomic_DNA.
DR EMBL; BC101433; AAI01434.1; -; mRNA.
DR EMBL; BC101434; AAI01435.1; -; mRNA.
DR EMBL; BC101435; AAI01436.1; -; mRNA.
DR EMBL; BC101436; AAI01437.1; -; mRNA.
DR EMBL; BC127955; AAI27956.1; -; mRNA.
DR CCDS; CCDS42146.1; -. [Q96LL3-1]
DR RefSeq; NP_001103129.1; NM_001109659.1. [Q96LL3-2]
DR RefSeq; NP_001103130.1; NM_001109660.1. [Q96LL3-1]
DR AlphaFoldDB; Q96LL3; -.
DR BioGRID; 126982; 17.
DR IntAct; Q96LL3; 10.
DR STRING; 9606.ENSP00000300575; -.
DR iPTMnet; Q96LL3; -.
DR PhosphoSitePlus; Q96LL3; -.
DR BioMuta; C16orf92; -.
DR PaxDb; Q96LL3; -.
DR PRIDE; Q96LL3; -.
DR DNASU; 146378; -.
DR Ensembl; ENST00000300575.6; ENSP00000300575.2; ENSG00000167194.8. [Q96LL3-1]
DR Ensembl; ENST00000681219.1; ENSP00000506393.1; ENSG00000167194.8. [Q96LL3-2]
DR GeneID; 146378; -.
DR KEGG; hsa:146378; -.
DR MANE-Select; ENST00000681219.1; ENSP00000506393.1; NM_001109659.2; NP_001103129.1. [Q96LL3-2]
DR UCSC; uc002dvs.2; human. [Q96LL3-1]
DR CTD; 146378; -.
DR DisGeNET; 146378; -.
DR GeneCards; C16orf92; -.
DR HGNC; HGNC:26346; C16orf92.
DR HPA; ENSG00000167194; Tissue enhanced (brain, retina, testis).
DR MIM; 618911; gene.
DR neXtProt; NX_Q96LL3; -.
DR PharmGKB; PA164716866; -.
DR VEuPathDB; HostDB:ENSG00000167194; -.
DR eggNOG; ENOG502RVJG; Eukaryota.
DR GeneTree; ENSGT00390000002780; -.
DR HOGENOM; CLU_163070_0_0_1; -.
DR InParanoid; Q96LL3; -.
DR OMA; NSEFFHH; -.
DR OrthoDB; 1443078at2759; -.
DR PhylomeDB; Q96LL3; -.
DR TreeFam; TF338342; -.
DR PathwayCommons; Q96LL3; -.
DR SignaLink; Q96LL3; -.
DR BioGRID-ORCS; 146378; 21 hits in 1052 CRISPR screens.
DR GenomeRNAi; 146378; -.
DR Pharos; Q96LL3; Tdark.
DR PRO; PR:Q96LL3; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96LL3; protein.
DR Bgee; ENSG00000167194; Expressed in right testis and 106 other tissues.
DR ExpressionAtlas; Q96LL3; baseline and differential.
DR Genevisible; Q96LL3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; ISS:UniProtKB.
DR InterPro; IPR038813; FIMP.
DR PANTHER; PTHR38648; PTHR38648; 1.
DR Pfam; PF17672; FIMP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Fertilization; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..132
FT /note="Fertilization-influencing membrane protein"
FT /id="PRO_0000321511"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..43
FT /note="MGAGVGVAGCTRGHRNWVPSQLPPREIKAGVSLAVVTEFAWVL -> MRLWP
FT WVLVWVWLAALGAIET (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031783"
SQ SEQUENCE 132 AA; 14383 MW; 379F1459C9891C61 CRC64;
MGAGVGVAGC TRGHRNWVPS QLPPREIKAG VSLAVVTEFA WVLAPRPKRA TASALGTESP
RFLDRPDFFD YPDSDQARLL AVAQFIGEKP IVFINSGSSP GLFHHILVGL LVVAFFFLLF
QFCTHINFQK GA
