ID   FINO2_ECOLX             Reviewed;         186 AA.
AC   P08315;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Fertility inhibition protein;
DE   AltName: Full=Conjugal transfer repressor;
GN   Name=finO;
OS   Escherichia coli.
OG   Plasmid IncFII R100 (NR1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3027040; DOI=10.1128/jb.169.2.619-623.1987;
RA   Yoshioka Y., Ohtsubo H., Ohtsubo E.;
RT   "Repressor gene finO in plasmids R100 and F: constitutive transfer of
RT   plasmid F is caused by insertion of IS3 into F finO.";
RL   J. Bacteriol. 169:619-623(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2951652; DOI=10.1093/nar/15.5.2029;
RA   McIntire S.A., Dempsey W.B.;
RT   "Fertility inhibition gene of plasmid R100.";
RL   Nucleic Acids Res. 15:2029-2042(1987).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2164585; DOI=10.1016/0022-2836(90)90145-c;
RA   Yoshioka Y., Fujita Y., Ohtsubo E.;
RT   "Nucleotide sequence of the promoter-distal region of the tra operon of
RT   plasmid R100, including traI (DNA helicase I) and traD genes.";
RL   J. Mol. Biol. 214:39-53(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-169.
RC   STRAIN=ATCC 35330 / ECOR 11 / UPEC, ATCC 35367 / ECOR 48 / UPEC, and
RC   ATCC 35377 / ECOR 58;
RX   PubMed=8807284; DOI=10.1093/genetics/143.3.1091;
RA   Boyd E.F., Hill C.W., Rich S.M., Hartl D.L.;
RT   "Mosaic structure of plasmids from natural populations of Escherichia
RT   coli.";
RL   Genetics 143:1091-1100(1996).
CC   -!- FUNCTION: One of the components on the FinOP fertility inhibition
CC       complex, which inhibits the expression of traJ gene, which in turn
CC       regulates the expression of some 20 transfer genes. The transfer genes
CC       are responsible for the process, called conjugal transfer, in which DNA
CC       is transmitted from one bacterial host to another. RNA-binding that
CC       interacts with the traJ mRNA and its antisense RNA, finP, stabilizing
CC       finP against endonucleolytic degradation and facilitating sense-
CC       antisense RNA recognition (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FinO family. {ECO:0000305}.
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DR   EMBL; M15196; AAA26061.1; -; Genomic_DNA.
DR   EMBL; X04878; CAA28566.1; -; Genomic_DNA.
DR   EMBL; X55815; CAA39341.1; -; Genomic_DNA.
DR   EMBL; U50703; AAC44287.1; -; Genomic_DNA.
DR   EMBL; U50692; AAC44276.1; -; Genomic_DNA.
DR   EMBL; U50701; AAC44285.1; -; Genomic_DNA.
DR   PIR; A27757; RPECTR.
DR   RefSeq; NP_957635.1; NC_005327.1.
DR   RefSeq; WP_000139321.1; NZ_WWEV01000027.1.
DR   RefSeq; YP_001096504.1; NC_009133.1.
DR   RefSeq; YP_003162609.1; NC_013175.1.
DR   RefSeq; YP_004870088.1; NC_016039.1.
DR   RefSeq; YP_009068652.1; NC_025141.1.
DR   RefSeq; YP_009071014.1; NC_025177.1.
DR   RefSeq; YP_190112.1; NC_006671.1.
DR   RefSeq; YP_443953.1; NC_007675.1.
DR   AlphaFoldDB; P08315; -.
DR   SMR; P08315; -.
DR   PRIDE; P08315; -.
DR   OMA; YVTEYIS; -.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1710.10; -; 1.
DR   InterPro; IPR021065; Fertility_inhibition_FinO_N.
DR   InterPro; IPR016103; ProQ/FinO.
DR   InterPro; IPR036442; ProQ/FinO_sf.
DR   Pfam; PF12602; FinO_N; 1.
DR   Pfam; PF04352; ProQ; 1.
DR   SMART; SM00945; ProQ; 1.
DR   SUPFAM; SSF48657; SSF48657; 1.
PE   3: Inferred from homology;
KW   Conjugation; Plasmid; Repressor; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..186
FT                   /note="Fertility inhibition protein"
FT                   /id="PRO_0000068351"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   186 AA;  21266 MW;  D563B0EB56E2805D CRC64;
     MTEQKRPVLT LKRKTEGETP TRSRKTIINV TTPPKWKVKK QKLAEKAARE AELTAKKAQA
     RQALSIYLNL PSLDEAVNTL KPWWPGLFDG DTPRLLACGI RDVLLEDVAQ RNIPLSHKKL
     RRALKAITRS ESYLCAMKAG ACRYDTEGYV TEHISQEEEV YAAERLDKIR RQNRIKAELQ
     AVLDEQ