ID   FINO4_ECOLX             Reviewed;         186 AA.
AC   Q05781;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Fertility inhibition protein;
DE   AltName: Full=Conjugal transfer repressor;
GN   Name=finO;
OS   Escherichia coli.
OG   Plasmid IncFII ColB2.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1374147; DOI=10.1111/j.1365-2958.1992.tb01527.x;
RA   van Biesen T., Frost L.S.;
RT   "Differential levels of fertility inhibition among F-like plasmids are
RT   related to the cellular concentration of finO mRNA.";
RL   Mol. Microbiol. 6:771-780(1992).
CC   -!- FUNCTION: One of the components on the FinOP fertility inhibition
CC       complex, which inhibits the expression of traJ gene, which in turn
CC       regulates the expression of some 20 transfer genes. The transfer genes
CC       are responsible for the process, called conjugal transfer, in which DNA
CC       is transmitted from one bacterial host to another. RNA-binding that
CC       interacts with the traJ mRNA and its antisense RNA, finP, stabilizing
CC       finP against endonucleolytic degradation and facilitating sense-
CC       antisense RNA recognition (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FinO family. {ECO:0000305}.
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DR   EMBL; X62481; CAA44348.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q05781; -.
DR   SMR; Q05781; -.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1710.10; -; 1.
DR   InterPro; IPR021065; Fertility_inhibition_FinO_N.
DR   InterPro; IPR016103; ProQ/FinO.
DR   InterPro; IPR036442; ProQ/FinO_sf.
DR   Pfam; PF12602; FinO_N; 1.
DR   Pfam; PF04352; ProQ; 1.
DR   SMART; SM00945; ProQ; 1.
DR   SUPFAM; SSF48657; SSF48657; 1.
PE   3: Inferred from homology;
KW   Conjugation; Plasmid; Repressor; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..186
FT                   /note="Fertility inhibition protein"
FT                   /id="PRO_0000068353"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   186 AA;  21115 MW;  E41E6C89913B6F9F CRC64;
     MTEQKRPVLT LKRKTEGETP VRSRKTIINV TTPPKWKVKK QKLAEKAARE AELAAKKAQA
     RQALSIYLNL PSLDEAVNTL KPWWPGLFDG DTPRLLACGI RDVLLEDVAH GNIPLSHKKL
     RRALKAITRS ESYLCAMKAG ACRYDTEGYV TEHISQEEEA YAAERLDKIR RQNRIKAELQ
     AVLDEK