ID   FINO_ECO57              Reviewed;         186 AA.
AC   O82922;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Fertility inhibition protein;
DE   AltName: Full=Conjugal transfer repressor;
GN   Name=finO; OrderedLocusNames=L7001, ECO57PM64;
OS   Escherichia coli O157:H7.
OG   Plasmid pO157.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=9722640; DOI=10.1093/nar/26.18.4196;
RA   Burland V., Shao Y., Perna N.T., Plunkett G. III, Sofia H.J.,
RA   Blattner F.R.;
RT   "The complete DNA sequence and analysis of the large virulence plasmid of
RT   Escherichia coli O157:H7.";
RL   Nucleic Acids Res. 26:4196-4204(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=9628576; DOI=10.1093/dnares/5.1.1;
RA   Makino K., Ishii K., Yasunaga T., Hattori M., Yokoyama K., Yatsudo H.C.,
RA   Kubota Y., Yamaichi Y., Iida T., Yamamoto K., Honda T., Han C.G.,
RA   Ohtsubo A., Kasamatsu M., Hayashi T., Kuhara S., Shinagawa H.;
RT   "Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an
RT   enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak.";
RL   DNA Res. 5:1-9(1998).
CC   -!- FUNCTION: One of the components on the FinOP fertility inhibition
CC       complex, which inhibits the expression of traJ gene, which in turn
CC       regulates the expression of some 20 transfer genes. The transfer genes
CC       are responsible for the process, called conjugal transfer, in which DNA
CC       is transmitted from one bacterial host to another. RNA-binding that
CC       interacts with the traJ mRNA and its antisense RNA, finP, stabilizing
CC       finP against endonucleolytic degradation and facilitating sense-
CC       antisense RNA recognition (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FinO family. {ECO:0000305}.
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DR   EMBL; AF074613; AAC70069.1; -; Genomic_DNA.
DR   EMBL; AB011549; BAA31821.1; -; Genomic_DNA.
DR   PIR; T00302; T00302.
DR   RefSeq; NP_052671.1; NC_002128.1.
DR   RefSeq; WP_000840472.1; NZ_SWKA01000002.1.
DR   AlphaFoldDB; O82922; -.
DR   SMR; O82922; -.
DR   STRING; 155864.EDL933_p0001; -.
DR   EnsemblBacteria; AAC70069; AAC70069; Z_L7001.
DR   EnsemblBacteria; BAA31821; BAA31821; BAA31821.
DR   GeneID; 1789697; -.
DR   KEGG; ece:Z_L7001; -.
DR   KEGG; ecs:pO157p64; -.
DR   PATRIC; fig|386585.9.peg.73; -.
DR   eggNOG; COG3109; Bacteria.
DR   HOGENOM; CLU_120874_0_0_6; -.
DR   OMA; YVTEYIS; -.
DR   Proteomes; UP000000558; Plasmid pO157.
DR   Proteomes; UP000002519; Plasmid pO157.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1710.10; -; 1.
DR   InterPro; IPR021065; Fertility_inhibition_FinO_N.
DR   InterPro; IPR016103; ProQ/FinO.
DR   InterPro; IPR036442; ProQ/FinO_sf.
DR   Pfam; PF12602; FinO_N; 1.
DR   Pfam; PF04352; ProQ; 1.
DR   SMART; SM00945; ProQ; 1.
DR   SUPFAM; SSF48657; SSF48657; 1.
PE   3: Inferred from homology;
KW   Conjugation; Plasmid; Reference proteome; Repressor; RNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..186
FT                   /note="Fertility inhibition protein"
FT                   /id="PRO_0000068350"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   186 AA;  21147 MW;  0A8505FD00A6284B CRC64;
     MAEQKRPVLT LKRKTEGETP VRSRKTIINV TTPPKWKVKK QKLAEKAARE AELAAKKAQA
     RQALSIYLNL PTQDEAVNTL KPWWPGLFDG DTPRLLACGI RDVLLEDVAQ RNIPLSHKKL
     RRALKAITRS ESYLCAMKAG ACRYDTEGYV TEHISQEEEA YAAARLDKIR RQNRIKAELQ
     AVLDEK