ID   FIP1_KLULA              Reviewed;         295 AA.
AC   Q6CPC3;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Pre-mRNA polyadenylation factor FIP1;
GN   Name=FIP1; OrderedLocusNames=KLLA0E05940g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Pre-mRNA polyadenylation factor that directly interacts with
CC       poly(A) polymerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FIP1 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99303.1; -; Genomic_DNA.
DR   RefSeq; XP_454216.1; XM_454216.1.
DR   AlphaFoldDB; Q6CPC3; -.
DR   SMR; Q6CPC3; -.
DR   STRING; 28985.XP_454216.1; -.
DR   EnsemblFungi; CAG99303; CAG99303; KLLA0_E05985g.
DR   GeneID; 2894528; -.
DR   KEGG; kla:KLLA0_E05985g; -.
DR   eggNOG; KOG1049; Eukaryota.
DR   HOGENOM; CLU_039307_2_1_1; -.
DR   InParanoid; Q6CPC3; -.
DR   OMA; GFNEYTW; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:EnsemblFungi.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:EnsemblFungi.
DR   GO; GO:0006378; P:mRNA polyadenylation; IEA:EnsemblFungi.
DR   GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IEA:EnsemblFungi.
DR   InterPro; IPR007854; Fip1_dom.
DR   Pfam; PF05182; Fip1; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome.
FT   CHAIN           1..295
FT                   /note="Pre-mRNA polyadenylation factor FIP1"
FT                   /id="PRO_0000238514"
FT   REGION          1..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..74
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   295 AA;  32618 MW;  BC1C367EA18369EB CRC64;
     MSSEDEDDKF LYSDEEDSNV VAKQEGPALK RQKVEETPKI LAHDVPEGNT NEVESEASNQ
     DSSSDEDDSS DSDSDVEIII GTGNDTSKID SGKSQISAIT DTTPLGTADH AIAAVAGISD
     VVPVQEGSIP PEQQQQQQQT IDLNPDAQFD GKPIVQIDPE ILKEKPWRQP GANISDYFNY
     GFNEQTWMEY LHRQEHLTKE YNPQKILMNL LALQQQGKLN DPGSGQPVQN TIQPPPPPMG
     LPPMFGGFPG FPFPGMMNNM QNQNVSSMNN MNNMNNMNNM NNINNNNNNN LNDKK