ID   FIP1_NEUCR              Reviewed;         423 AA.
AC   Q7SAX8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Pre-mRNA polyadenylation factor fip-1;
GN   Name=fip-1; ORFNames=NCU07654;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Pre-mRNA polyadenylation factor that directly interacts with
CC       poly(A) polymerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FIP1 family. {ECO:0000305}.
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DR   EMBL; CM002239; EAA33545.1; -; Genomic_DNA.
DR   RefSeq; XP_962781.1; XM_957688.2.
DR   AlphaFoldDB; Q7SAX8; -.
DR   SMR; Q7SAX8; -.
DR   STRING; 5141.EFNCRP00000007700; -.
DR   PRIDE; Q7SAX8; -.
DR   EnsemblFungi; EAA33545; EAA33545; NCU07654.
DR   GeneID; 3878929; -.
DR   KEGG; ncr:NCU07654; -.
DR   VEuPathDB; FungiDB:NCU07654; -.
DR   HOGENOM; CLU_039307_1_0_1; -.
DR   InParanoid; Q7SAX8; -.
DR   OMA; FDEFTWE; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IBA:GO_Central.
DR   InterPro; IPR007854; Fip1_dom.
DR   Pfam; PF05182; Fip1; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome.
FT   CHAIN           1..423
FT                   /note="Pre-mRNA polyadenylation factor fip-1"
FT                   /id="PRO_0000238515"
FT   REGION          1..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..89
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..164
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  42229 MW;  42188E3BB40F740F CRC64;
     MDIDEDEDFY APDEPQAAPP TTAATTTTPA TTTTTAAPTT TTTTTSTTTA SAPPTTTSSS
     TKPEDELEEG EEEDEGGGAM DEDDDSDIDI ITERKDGSAP PPPVQSRYSE IRNIPQRAAA
     NDNGVKTAPV KKSDGTNSNS NSSSNKFGGG GGIGNEQKTR QGSGAAGGSG AELPPVRTSK
     IEVDGIPVYK PVGKPITGVV IDEDLPENDK PWRKPGTDLS DYFNYGFDEF TWALYAQKQE
     ALRGEYNAEA IAANNKKMME EMTNMMMMGG MMPPGMGGPG GPGVGPAGPG AMGPGGPAGA
     GGMGGPGGGL DGMPPEMQAM MQQMMGAAAA QGMDPSQMGQ MGMAGGPGDM GGMGGMFGGP
     GGGPGGPGTG GMGPGGPGGQ GGQGQQFGGG FGGNQGQGGY GGYDQMGGAG GGGRGGRGRG
     RRW