FIP1_SCHPO
ID FIP1_SCHPO Reviewed; 397 AA.
AC Q09919;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Plasma membrane iron permease;
GN Name=fip1; ORFNames=SPAC1F7.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=8995275; DOI=10.1074/jbc.272.1.401;
RA Askwith C., Kaplan J.;
RT "An oxidase-permease-based iron transport system in Schizosaccharomyces
RT pombe and its expression in Saccharomyces cerevisiae.";
RL J. Biol. Chem. 272:401-405(1997).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337; SER-338; THR-340;
RP SER-346; SER-347; SER-355; THR-357; SER-374; SER-375 AND SER-376, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Permease for high affinity iron uptake.
CC {ECO:0000269|PubMed:8995275}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC
CC 9.A.10.1) family. {ECO:0000305}.
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DR EMBL; CU329670; CAA91954.1; -; Genomic_DNA.
DR PIR; S62579; S62579.
DR RefSeq; NP_594493.1; NM_001019922.2.
DR AlphaFoldDB; Q09919; -.
DR BioGRID; 278056; 2.
DR STRING; 4896.SPAC1F7.07c.1; -.
DR TCDB; 2.A.108.1.5; the iron/lead transporter (ilt) family.
DR iPTMnet; Q09919; -.
DR MaxQB; Q09919; -.
DR PaxDb; Q09919; -.
DR PRIDE; Q09919; -.
DR EnsemblFungi; SPAC1F7.07c.1; SPAC1F7.07c.1:pep; SPAC1F7.07c.
DR GeneID; 2541557; -.
DR KEGG; spo:SPAC1F7.07c; -.
DR PomBase; SPAC1F7.07c; fip1.
DR VEuPathDB; FungiDB:SPAC1F7.07c; -.
DR eggNOG; ENOG502QQWE; Eukaryota.
DR HOGENOM; CLU_046738_1_1_1; -.
DR InParanoid; Q09919; -.
DR OMA; ITMLKMD; -.
DR PhylomeDB; Q09919; -.
DR PRO; PR:Q09919; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0033573; C:high-affinity iron permease complex; IGI:PomBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0061840; F:high-affinity ferrous iron transmembrane transporter activity; IGI:PomBase.
DR GO; GO:0034755; P:iron ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0033215; P:reductive iron assimilation; IGI:PomBase.
DR InterPro; IPR004923; FTR1/Fip1/EfeU.
DR PANTHER; PTHR31632; PTHR31632; 1.
DR Pfam; PF03239; FTR1; 1.
PE 1: Evidence at protein level;
KW Ion transport; Iron; Iron transport; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..397
FT /note="Plasma membrane iron permease"
FT /id="PRO_0000159651"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 337..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 337
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 338
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 340
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 346
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 347
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 357
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 374
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 375
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 376
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 397 AA; 44315 MW; 1D98E41AD1FD708F CRC64;
MAKDVFSVAI FFIVLRETLE ASIIVSVLMS FISQTLMDKD GNVTDPKLKR KFMLQVWIGS
FTALFICLAI GGGFIGAFYA LDKDIWSGSE EIWEGVFSLI AVVLITVMGF AMLRVSHLQE
KWRKKLMKSI ANRKAKGISN WGKKYSMFLL PFFTVLREGL EVVVFVGGVG LETPATAFPL
PVICGLIVGC LIGYFIYRGG NVMNLQWFLI ASTCILYLIS AGLMSKATFY FEMNKWNHQT
GGDAGELGDG PGSYPFKSAV WHVNYGNPEM NSNGGYMIFN AILGWNNTGT YGSILSYIIY
WLFVAFIMFL MWYKERRAAR LLIAKLGDKV VDLEAASSHT PVQSSSSEDE FKINSPTDDK
GDKAIDIVTE VRESSSPVEE HKDDKTVDVI NEIRESH
