ID   FIRA_PLAFF              Reviewed;         310 AA.
AC   P06916;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=300 kDa antigen AG231;
DE   Flags: Fragment;
GN   Name=FIRA;
OS   Plasmodium falciparum (isolate FC27 / Papua New Guinea).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5837;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3881769; DOI=10.1073/pnas.82.2.543;
RA   Stahl H.-D., Crewther P.E., Anders R.F., Brown G.V., Coppel R.L.,
RA   Bianco A.E., Mitchell G.F., Kemp D.J.;
RT   "Interspersed blocks of repetitive and charged amino acids in a dominant
RT   immunogen of Plasmodium falciparum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:543-547(1985).
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DR   EMBL; M10236; AAA29468.1; -; mRNA.
DR   PIR; A21890; YAZQ31.
DR   AlphaFoldDB; P06916; -.
DR   InterPro; IPR009745; CRAM_rpt.
DR   Pfam; PF07016; CRAM_rpt; 1.
PE   2: Evidence at transcript level;
KW   Malaria; Merozoite; Repeat.
FT   CHAIN           <1..>310
FT                   /note="300 kDa antigen AG231"
FT                   /id="PRO_0000217184"
FT   REPEAT          107..152
FT                   /note="45 AA repeat 1"
FT   REPEAT          266..310
FT                   /note="45 AA repeat 2"
FT   REGION          <1..23
FT                   /note="4 X 6 AA tandem repeats of V-V-T-G-S-C"
FT   REGION          29..106
FT                   /note="13 X 6 AA tandem repeats of V-V-[TI]-[QE]-E-[PH]"
FT   REGION          53..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..265
FT                   /note="13 X 6 AA approximate tandem repeats"
FT   COMPBIAS        53..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..310
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         310
SQ   SEQUENCE   310 AA;  33968 MW;  66463E0361E12CD7 CRC64;
     VTGSCVVTGS CVVTDSCVVT GSCGNTRTVT TQESVTTQEP VTIEEPVTTQ EPVTIEEPVT
     TQEPVTIEEP VTTQEPVTTQ EPVTTQEPVT TQEPVTTQEP VTVEEHIDEK KGSEGDNISL
     SSLSEETEEK SHTKKKKSSW LKFGRGNKND KKSKNEKKPS LESVKQNADE QKEQPTDSQI
     SVNAQDSVTI QEPTATQEPP TTQELTATQE PTTTQETVTE QEPTTTQETV TAQEPITTQE
     PVTAQEPVTT QELIATQEPS TTQEHADEKK ASEGDNISLS RLSEETEEKS HTKKKSSWLK
     FGRGNKNDKK