ID   AKH_MANSE               Reviewed;          65 AA.
AC   P67788; P08901;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Adipokinetic prohormone;
DE   Contains:
DE     RecName: Full=Adipokinetic hormone;
DE              Short=AKH;
DE   Flags: Precursor;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2753887; DOI=10.1016/s0021-9258(18)51555-6;
RA   Bradfield J.Y., Keeley L.L.;
RT   "Adipokinetic hormone gene sequence from Manduca sexta.";
RL   J. Biol. Chem. 264:12791-12793(1989).
RN   [2]
RP   PROTEIN SEQUENCE OF 20-28, PYROGLUTAMATE FORMATION AT GLN-20, AND AMIDATION
RP   AT GLY-28.
RX   PubMed=4074373; DOI=10.1016/0006-291x(85)91880-7;
RA   Ziegler R., Eckart K., Schwarz H., Keller R.;
RT   "Amino acid sequence of Manduca sexta adipokinetic hormone elucidated by
RT   combined fast atom bombardment (FAB)/tandem mass spectrometry.";
RL   Biochem. Biophys. Res. Commun. 133:337-342(1985).
CC   -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC       causes release of diglycerides from the fat body and stimulation of
CC       muscles to use these diglycerides as an energy source during energy-
CC       demanding processes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   EMBL; J04972; AAA29299.1; -; Genomic_DNA.
DR   PIR; A32613; A32613.
DR   AlphaFoldDB; P67788; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   InterPro; IPR010475; AKH/RPCH_hormone.
DR   Pfam; PF06377; Adipokin_hormo; 1.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Flight; Hormone; Neuropeptide; Pyrrolidone carboxylic acid; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:4074373"
FT   CHAIN           20..65
FT                   /note="Adipokinetic prohormone"
FT                   /id="PRO_0000000914"
FT   PEPTIDE         20..28
FT                   /note="Adipokinetic hormone"
FT                   /id="PRO_0000000915"
FT   MOD_RES         20
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:4074373"
FT   MOD_RES         28
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:4074373"
SQ   SEQUENCE   65 AA;  7401 MW;  1812E58E6F2D7852 CRC64;
     MYKLTVFLMF IAFVIIAEAQ LTFTSSWGGK RAMTNSISCR NDEAIAAIYK AIQNEAERFI
     MCQKN