ID   FIS1_CHAGB              Reviewed;         160 AA.
AC   Q2H047;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Mitochondrial fission 1 protein;
GN   Name=FIS1; ORFNames=CHGG_04849;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Has a role in mitochondrial fission. Has a role in outer
CC       membrane fission but not matrix separation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The C-terminus is required for mitochondrial localization,
CC       while the N-terminus is necessary for mitochondrial fission.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FIS1 family. {ECO:0000305}.
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DR   EMBL; CH408032; EAQ88230.1; -; Genomic_DNA.
DR   RefSeq; XP_001224063.1; XM_001224062.1.
DR   AlphaFoldDB; Q2H047; -.
DR   SMR; Q2H047; -.
DR   STRING; 38033.XP_001224063.1; -.
DR   PRIDE; Q2H047; -.
DR   EnsemblFungi; EAQ88230; EAQ88230; CHGG_04849.
DR   GeneID; 4391845; -.
DR   eggNOG; KOG3364; Eukaryota.
DR   HOGENOM; CLU_104368_2_0_1; -.
DR   InParanoid; Q2H047; -.
DR   OMA; VTIQTKF; -.
DR   OrthoDB; 1595957at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000266; P:mitochondrial fission; IEA:InterPro.
DR   CDD; cd12212; Fis1; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR016543; Fis1.
DR   InterPro; IPR033745; Fis1_cytosol.
DR   InterPro; IPR028061; Fis1_TPR_C.
DR   InterPro; IPR028058; Fis1_TPR_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13247; PTHR13247; 1.
DR   Pfam; PF14853; Fis1_TPR_C; 1.
DR   Pfam; PF14852; Fis1_TPR_N; 1.
DR   PIRSF; PIRSF008835; TPR_repeat_11_Fis1; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..160
FT                   /note="Mitochondrial fission 1 protein"
FT                   /id="PRO_0000256182"
FT   TOPO_DOM        1..124
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..160
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REPEAT          73..106
FT                   /note="TPR"
SQ   SEQUENCE   160 AA;  17623 MW;  A31978FDBEC13227 CRC64;
     MAQLPYAIDA ETPLNPAELA VLRAQYEREG DMVGLQTKFN YAWVKLNFAP LMEQQLGVML
     LAEIFRVSTE RRRECLYYLG LGNYKLGNYG DARKYNDILL SKEPGNLQAL NLQSLIDEKV
     AKEGLMGVAI VSGVAVVAGI VGECAAPEFG AEEVKTTLLH