ID   FIS1_CRYNJ              Reviewed;         154 AA.
AC   P0CN70; Q55SZ9; Q5KHD1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Mitochondrial fission 1 protein;
GN   Name=FIS1; OrderedLocusNames=CNE00460;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Has a role in mitochondrial fission. Has a role in outer
CC       membrane fission but not matrix separation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The C-terminus is required for mitochondrial localization,
CC       while the N-terminus is necessary for mitochondrial fission.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FIS1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW43445.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017345; AAW43445.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_570752.1; XM_570752.1.
DR   AlphaFoldDB; P0CN70; -.
DR   SMR; P0CN70; -.
DR   STRING; 5207.AAW43445; -.
DR   PaxDb; P0CN70; -.
DR   EnsemblFungi; AAW43445; AAW43445; CNE00460.
DR   VEuPathDB; FungiDB:CNE00460; -.
DR   eggNOG; KOG3364; Eukaryota.
DR   InParanoid; P0CN70; -.
DR   OrthoDB; 1595957at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR   GO; GO:0016559; P:peroxisome fission; IBA:GO_Central.
DR   CDD; cd12212; Fis1; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR016543; Fis1.
DR   InterPro; IPR033745; Fis1_cytosol.
DR   InterPro; IPR028061; Fis1_TPR_C.
DR   InterPro; IPR028058; Fis1_TPR_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13247; PTHR13247; 1.
DR   Pfam; PF14853; Fis1_TPR_C; 1.
DR   Pfam; PF14852; Fis1_TPR_N; 1.
DR   PIRSF; PIRSF008835; TPR_repeat_11_Fis1; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..154
FT                   /note="Mitochondrial fission 1 protein"
FT                   /id="PRO_0000256183"
FT   TOPO_DOM        1..127
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..154
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REPEAT          76..109
FT                   /note="TPR"
SQ   SEQUENCE   154 AA;  17334 MW;  344839A9D4B1BCE8 CRC64;
     MPTDLPYAAE AESSLSPDEL EVLRRQYYRE IEQGHVTIQS KFNYGWGLIK SPSPELETEG
     VKLLQEIYSA SPDHRRECTY YIAVGYYKLR NYAYARKFNN LLLSVEPGNM QAQSLSTLIE
     NAVKRDGLVG IGMITGAVAV VGLIAGSVWK RSRR