ID   FIS1_YARLI              Reviewed;         154 AA.
AC   Q6CFJ0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Mitochondrial fission 1 protein;
GN   Name=FIS1; OrderedLocusNames=YALI0B06556g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has a role in mitochondrial fission. Has a role in outer
CC       membrane fission but not matrix separation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The C-terminus is required for mitochondrial localization,
CC       while the N-terminus is necessary for mitochondrial fission.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FIS1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG82803.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR382128; CAG82803.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_500572.1; XM_500572.1.
DR   AlphaFoldDB; Q6CFJ0; -.
DR   SMR; Q6CFJ0; -.
DR   STRING; 4952.CAG82803; -.
DR   GeneID; 2907409; -.
DR   KEGG; yli:YALI0B06556g; -.
DR   InParanoid; Q6CFJ0; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR   GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central.
DR   GO; GO:0016559; P:peroxisome fission; IBA:GO_Central.
DR   CDD; cd12212; Fis1; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR016543; Fis1.
DR   InterPro; IPR033745; Fis1_cytosol.
DR   InterPro; IPR028061; Fis1_TPR_C.
DR   InterPro; IPR028058; Fis1_TPR_N.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13247; PTHR13247; 1.
DR   Pfam; PF14853; Fis1_TPR_C; 1.
DR   Pfam; PF14852; Fis1_TPR_N; 1.
DR   PIRSF; PIRSF008835; TPR_repeat_11_Fis1; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..154
FT                   /note="Mitochondrial fission 1 protein"
FT                   /id="PRO_0000256192"
FT   TOPO_DOM        1..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..154
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REPEAT          76..109
FT                   /note="TPR"
SQ   SEQUENCE   154 AA;  17392 MW;  42394C3AD4C74AFD CRC64;
     MKKEDYLPNL VDIESPLSDE ELYVLSQQYN NEGDFVSVQT RFNYAWGLIK SRKVEDQQLG
     VQILAQVYKD TPSRRRECLY YLAIGSYKLG EYTDARKYCD LLLQIEPDDP QSAKLRQIIE
     DKLAKEGMIG IAIVGGVIAV GAAVLGAVLS QKKR