ID   FIS_HISS2               Reviewed;          98 AA.
AC   B0UV86;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=DNA-binding protein Fis {ECO:0000255|HAMAP-Rule:MF_00166};
GN   Name=fis {ECO:0000255|HAMAP-Rule:MF_00166}; OrderedLocusNames=HSM_1610;
OS   Histophilus somni (strain 2336) (Haemophilus somnus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=228400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2336;
RG   US DOE Joint Genome Institute;
RA   Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F.,
RA   Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M.,
RA   Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S.,
RA   Dyer D.W., Inzana T.J.;
RT   "Complete sequence of Haemophilus somnus 2336.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activates ribosomal RNA transcription. Plays a direct role in
CC       upstream activation of rRNA promoters. {ECO:0000255|HAMAP-
CC       Rule:MF_00166}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00166}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory Fis family.
CC       {ECO:0000255|HAMAP-Rule:MF_00166}.
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DR   EMBL; CP000947; ACA31375.1; -; Genomic_DNA.
DR   RefSeq; WP_011608721.1; NC_010519.1.
DR   AlphaFoldDB; B0UV86; -.
DR   SMR; B0UV86; -.
DR   STRING; 228400.HSM_1610; -.
DR   EnsemblBacteria; ACA31375; ACA31375; HSM_1610.
DR   GeneID; 56964632; -.
DR   KEGG; hsm:HSM_1610; -.
DR   HOGENOM; CLU_158040_3_0_6; -.
DR   OMA; MVLCEVE; -.
DR   OrthoDB; 1933378at2; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   HAMAP; MF_00166; DNA_binding_Fis; 1.
DR   InterPro; IPR005412; Fis_DNA-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   Pfam; PF02954; HTH_8; 1.
DR   PIRSF; PIRSF002097; DNA-binding_Fis; 1.
DR   PRINTS; PR01591; DNABINDNGFIS.
DR   PRINTS; PR01590; HTHFIS.
DR   SUPFAM; SSF46689; SSF46689; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..98
FT                   /note="DNA-binding protein Fis"
FT                   /id="PRO_1000076981"
FT   DNA_BIND        74..93
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00166"
SQ   SEQUENCE   98 AA;  11109 MW;  82BAC76B04933778 CRC64;
     MLEQRNPAEA LTVSVLNSQS QVTNKPLRDS VKQALRNYLS QLDGQDVNDL YELVLAEVEH
     PMLDMIMQYT RGNQTRAATM LGINRGTLRK KLKKYGMG