FIS_PROVU
ID FIS_PROVU Reviewed; 93 AA.
AC P0CW85; O52534; Q84AP2;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 1.
DT 25-MAY-2022, entry version 22.
DE RecName: Full=DNA-binding protein Fis {ECO:0000255|HAMAP-Rule:MF_00166};
DE Flags: Fragment;
GN Name=fis {ECO:0000255|HAMAP-Rule:MF_00166};
OS Proteus vulgaris.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Proteus.
OX NCBI_TaxID=585;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9811652; DOI=10.1128/jb.180.22.5932-5946.1998;
RA Beach M.B., Osuna R.;
RT "Identification and characterization of the fis operon in enteric
RT bacteria.";
RL J. Bacteriol. 180:5932-5946(1998).
CC -!- FUNCTION: Activates ribosomal RNA transcription. Plays a direct role in
CC upstream activation of rRNA promoters. {ECO:0000255|HAMAP-
CC Rule:MF_00166}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00166}.
CC -!- SIMILARITY: Belongs to the transcriptional regulatory Fis family.
CC {ECO:0000255|HAMAP-Rule:MF_00166}.
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DR EMBL; AF040379; AAC77885.1; -; Genomic_DNA.
DR AlphaFoldDB; P0CW85; -.
DR SMR; P0CW85; -.
DR STRING; 585.DR95_2015; -.
DR eggNOG; COG2901; Bacteria.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR HAMAP; MF_00166; DNA_binding_Fis; 1.
DR InterPro; IPR005412; Fis_DNA-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR Pfam; PF02954; HTH_8; 1.
DR PIRSF; PIRSF002097; DNA-binding_Fis; 1.
DR PRINTS; PR01591; DNABINDNGFIS.
DR PRINTS; PR01590; HTHFIS.
DR SUPFAM; SSF46689; SSF46689; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..>93
FT /note="DNA-binding protein Fis"
FT /id="PRO_0000408965"
FT DNA_BIND 74..93
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00166"
FT NON_TER 93
SQ SEQUENCE 93 AA; 10645 MW; 74F7C263C3AB8DF3 CRC64;
MFEQRVNSDV LTVATVNSQD QVTQKPLRDS VKQALKNYFA QLNGQDVNDL YELVLAEVEQ
PLLDMVMQYT RGNQTRAAQM MGINRGTLRK KLK