ID   AKH_TABAT               Reviewed;           8 AA.
AC   P14595;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   02-JUN-2021, entry version 62.
DE   RecName: Full=Adipokinetic hormone;
DE            Short=AKH;
DE   AltName: Full=Dipteran corpora cardiaca factor I;
DE            Short=DCC I;
OS   Tabanus atratus (Black horse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=7207;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT TRP-8.
RC   TISSUE=Corpora cardiaca;
RX   PubMed=2813385; DOI=10.1073/pnas.86.20.8161;
RA   Jaffe H., Raina A.K., Riley C.T., Fraser B.A., Nachman R.J., Vogel V.W.,
RA   Zhang Y.-S., Hayes D.K.;
RT   "Primary structure of two neuropeptide hormones with adipokinetic and
RT   hypotrehalosemic activity isolated from the corpora cardiaca of horse flies
RT   (Diptera).";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:8161-8164(1989).
CC   -!- FUNCTION: This hormone, released from cells in the corpora cardiaca,
CC       causes release of diglycerides from the fat body and stimulation of
CC       muscles to use these diglycerides as an energy source during energy-
CC       demanding processes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
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DR   PIR; A33995; A33995.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007629; P:flight behavior; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR002047; Adipokinetic_hormone_CS.
DR   PROSITE; PS00256; AKH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Flight; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Adipokinetic hormone"
FT                   /id="PRO_0000043425"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2813385"
FT   MOD_RES         8
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:2813385"
SQ   SEQUENCE   8 AA;  949 MW;  86786771A9D1A736 CRC64;
     QLTFTPGW