ID   AKIP1_MOUSE             Reviewed;         212 AA.
AC   Q9JJR5; Q3TR76;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=A-kinase-interacting protein 1;
DE   AltName: Full=Breast cancer-associated gene 3 protein;
DE   AltName: Full=PKA-interacting protein;
DE   AltName: Full=Proline-rich protein BCA3;
GN   Name=Akip1; Synonyms=Bca3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11528127; DOI=10.1159/000056999;
RA   Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A.,
RA   Zabel B., Hankeln T., Schmidt E.R.;
RT   "Comparative genomic sequencing reveals a strikingly similar architecture
RT   of a conserved syntenic region on human chromosome 11p15.3 (including gene
RT   ST5) and mouse chromosome 7.";
RL   Cytogenet. Cell Genet. 93:284-290(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: Enhances NF-kappa-B transcriptional activity by regulating
CC       the nuclear localization of the NF-kappa-B subunit RELA and promoting
CC       the phosphorylation of RELA by PRKACA. Regulates the effect of the
CC       cAMP-dependent protein kinase signaling pathway on the NF-kappa-B
CC       activation cascade (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PRKACA and RELA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Locates to punctate
CC       spots. {ECO:0000250}.
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DR   EMBL; AJ400878; CAB92298.1; -; Genomic_DNA.
DR   EMBL; AK086219; BAC39632.1; -; mRNA.
DR   EMBL; AK163012; BAE37154.1; -; mRNA.
DR   CCDS; CCDS21736.1; -.
DR   RefSeq; NP_065641.1; NM_020616.1.
DR   AlphaFoldDB; Q9JJR5; -.
DR   BioGRID; 208274; 1.
DR   STRING; 10090.ENSMUSP00000033335; -.
DR   iPTMnet; Q9JJR5; -.
DR   PhosphoSitePlus; Q9JJR5; -.
DR   MaxQB; Q9JJR5; -.
DR   PaxDb; Q9JJR5; -.
DR   PRIDE; Q9JJR5; -.
DR   ProteomicsDB; 296151; -.
DR   Antibodypedia; 24164; 241 antibodies from 26 providers.
DR   DNASU; 57373; -.
DR   Ensembl; ENSMUST00000033335; ENSMUSP00000033335; ENSMUSG00000031023.
DR   GeneID; 57373; -.
DR   KEGG; mmu:57373; -.
DR   UCSC; uc009jdy.1; mouse.
DR   CTD; 56672; -.
DR   MGI; MGI:3041226; Akip1.
DR   VEuPathDB; HostDB:ENSMUSG00000031023; -.
DR   eggNOG; ENOG502S6M5; Eukaryota.
DR   GeneTree; ENSGT00390000017064; -.
DR   HOGENOM; CLU_126629_1_0_1; -.
DR   InParanoid; Q9JJR5; -.
DR   OMA; DYASSQC; -.
DR   OrthoDB; 1398399at2759; -.
DR   PhylomeDB; Q9JJR5; -.
DR   TreeFam; TF337318; -.
DR   BioGRID-ORCS; 57373; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Akip1; mouse.
DR   PRO; PR:Q9JJR5; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q9JJR5; protein.
DR   Bgee; ENSMUSG00000031023; Expressed in right kidney and 223 other tissues.
DR   ExpressionAtlas; Q9JJR5; baseline and differential.
DR   Genevisible; Q9JJR5; MM.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR   GO; GO:1901222; P:regulation of NIK/NF-kappaB signaling; IEA:InterPro.
DR   GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IGI:MGI.
DR   InterPro; IPR033214; AKIP1.
DR   PANTHER; PTHR14330; PTHR14330; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..212
FT                   /note="A-kinase-interacting protein 1"
FT                   /id="PRO_0000064858"
SQ   SEQUENCE   212 AA;  23979 MW;  ABF9916CF5031C56 CRC64;
     MEYCLAAAAL NGVDRRSLQR SARLGREVLE RAKRRAVDWH SPERSRGNVG VLYRQGPYQE
     RWSVPGSQRL LGEREERCPT LSSSFGAMAE FMDYTSSQCG KYYLSMPEEG GATHVYRYHR
     RKPPEMHMYS DTGHSQEQRN CRGETSVGQE SIYQTSEHSQ ESSWPTENIS KDLYIEVYPG
     TYSVTVGSSA LSKKTHVVAV DPGQSVDLVF PV