ID   FITM1_DANRE             Reviewed;         290 AA.
AC   Q5CZN0;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Fat storage-inducing transmembrane protein 1 {ECO:0000250|UniProtKB:A5D6W6, ECO:0000255|HAMAP-Rule:MF_03229};
DE   AltName: Full=FITM1-like protein {ECO:0000255|HAMAP-Rule:MF_03229};
DE   AltName: Full=Fat-inducing protein 1 {ECO:0000255|HAMAP-Rule:MF_03229};
GN   Name=fitm1l;
GN   Synonyms=fit1 {ECO:0000255|HAMAP-Rule:MF_03229},
GN   fitm1 {ECO:0000255|HAMAP-Rule:MF_03229}; ORFNames=zgc:112967;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION AS FITM1.
RX   PubMed=18160536; DOI=10.1073/pnas.0708579105;
RA   Kadereit B., Kumar P., Wang W.-J., Miranda D., Snapp E.L., Severina N.,
RA   Torregroza I., Evans T., Silver D.L.;
RT   "Evolutionarily conserved gene family important for fat storage.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:94-99(2008).
CC   -!- FUNCTION: May play an important role in the formation of lipid droplets
CC       (LDs) which are storage organelles at the center of lipid and energy
CC       homeostasis (By similarity). May directly bind to diacylglycerol (DAGs)
CC       and triacylglycerol (By similarity). {ECO:0000255|HAMAP-Rule:MF_03229}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03229}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03229}.
CC   -!- SIMILARITY: Belongs to the FIT family. FIT1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03229}.
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DR   EMBL; BC090787; AAH90787.1; -; mRNA.
DR   RefSeq; NP_001013343.1; NM_001013325.2.
DR   AlphaFoldDB; Q5CZN0; -.
DR   STRING; 7955.ENSDARP00000073429; -.
DR   PaxDb; Q5CZN0; -.
DR   GeneID; 503747; -.
DR   CTD; 503747; -.
DR   ZFIN; ZDB-GENE-050306-28; fitm1l.
DR   eggNOG; KOG3750; Eukaryota.
DR   InParanoid; Q5CZN0; -.
DR   OrthoDB; 1621925at2759; -.
DR   PhylomeDB; Q5CZN0; -.
DR   Reactome; R-DRE-8964572; Lipid particle organization.
DR   PRO; PR:Q5CZN0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0019992; F:diacylglycerol binding; ISS:UniProtKB.
DR   GO; GO:0017129; F:triglyceride binding; ISS:UniProtKB.
DR   GO; GO:0140042; P:lipid droplet formation; ISS:UniProtKB.
DR   GO; GO:0034389; P:lipid droplet organization; IBA:GO_Central.
DR   GO; GO:0019915; P:lipid storage; IBA:GO_Central.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_03229; FITM1; 1.
DR   HAMAP; MF_03230; FITM2; 1.
DR   InterPro; IPR019388; FIT.
DR   InterPro; IPR046402; FIT1.
DR   InterPro; IPR046401; FITM1/2.
DR   PANTHER; PTHR23129; PTHR23129; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..290
FT                   /note="Fat storage-inducing transmembrane protein 1"
FT                   /id="PRO_0000350631"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   290 AA;  32458 MW;  E5E1CC56E78AB31D CRC64;
     MFLNSILVVI TDLAAGLLGN TSFRRHFHLL LSALLLFGPL LSLWVSHYSV FAKRTHFLYR
     VFLRSGWGWT CIFVGSFVFV LSFSVRRSLT LSLRHLSRLA VAGGLWLGFR KLLCLLENAT
     GSCYEPLSAA LEMTSGTNGE GQPLLLLREA ETKETCVRSG MLWRGYEVSE DALLLCLCCL
     LLAEETAVFG PYLNLGGPSE APLRILFLFC VLLLSLWVFL LLCLLAYFPE FPTQLLGGAL
     GCLSWRALYQ GWYRLRPSWY CPGRPGVGLL STQSKQDELL ETQTNAKEID