AKIP_HUMAN
ID AKIP_HUMAN Reviewed; 199 AA.
AC Q9NWT8; Q5TA36; Q8TBD3;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Aurora kinase A-interacting protein;
DE Short=AURKA-interacting protein;
DE AltName: Full=28S ribosomal protein S38, mitochondrial;
DE Short=MRP-S38;
DE AltName: Full=Mitochondrial small ribosomal subunit protein mS38 {ECO:0000303|PubMed:25838379};
GN Name=AURKAIP1; Synonyms=AIP, AKIP, MRPS38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH AURORA-A.
RX PubMed=12244051; DOI=10.1074/jbc.m206820200;
RA Kiat L.S., Hui K.M., Gopalan G.;
RT "Aurora-A kinase interacting protein (AIP), a novel negative regulator of
RT human Aurora-A kinase.";
RL J. Biol. Chem. 277:45558-45565(2002).
RN [5]
RP SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=23908630; DOI=10.3389/fphys.2013.00183;
RA Koc E.C., Cimen H., Kumcuoglu B., Abu N., Akpinar G., Haque M.E.,
RA Spremulli L.L., Koc H.;
RT "Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new
RT members of the mammalian mitochondrial ribosome.";
RL Front. Physiol. 4:183-183(2013).
RN [6]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), AND SUBUNIT.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
CC -!- FUNCTION: May act as a negative regulator of Aurora-A kinase, by down-
CC regulation through proteasome-dependent degradation.
CC -!- SUBUNIT: Component of the mitochondrial small ribosomal subunit (mt-
CC SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small
CC (28S) and a large (39S) subunit. The 28S small subunit contains a 12S
CC ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large
CC subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial
CC valine transfer RNA (mt-tRNA(Val)), which plays an integral structural
CC role, and 52 different proteins (PubMed:23908630, PubMed:25838379).
CC Interacts with Aurora-A (PubMed:12244051).
CC {ECO:0000269|PubMed:12244051, ECO:0000269|PubMed:23908630,
CC ECO:0000269|PubMed:25838379}.
CC -!- INTERACTION:
CC Q9NWT8; Q8TB40: ABHD4; NbExp=3; IntAct=EBI-448665, EBI-7131019;
CC Q9NWT8; O14965: AURKA; NbExp=2; IntAct=EBI-448665, EBI-448680;
CC Q9NWT8; Q9H1M4: DEFB127; NbExp=3; IntAct=EBI-448665, EBI-10305240;
CC Q9NWT8; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-448665, EBI-10175124;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23908630}.
CC Nucleus {ECO:0000269|PubMed:23908630}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed and especially highly
CC expressed in heart, skeletal muscle and testis.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS38 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22808.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK000615; BAA91289.1; -; mRNA.
DR EMBL; AL139287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022808; AAH22808.1; ALT_INIT; mRNA.
DR EMBL; BC062333; AAH62333.1; -; mRNA.
DR CCDS; CCDS25.1; -.
DR RefSeq; NP_001120701.1; NM_001127229.1.
DR RefSeq; NP_001120702.1; NM_001127230.1.
DR RefSeq; NP_060370.1; NM_017900.2.
DR PDB; 3J9M; EM; 3.50 A; A3=1-199.
DR PDB; 6NU2; EM; 3.90 A; A3=128-196.
DR PDB; 6NU3; EM; 4.40 A; A3=1-199.
DR PDB; 6RW4; EM; 2.97 A; 3=1-199.
DR PDB; 6RW5; EM; 3.14 A; 3=1-199.
DR PDB; 6VLZ; EM; 2.97 A; A3=1-199.
DR PDB; 6VMI; EM; 2.96 A; A3=1-199.
DR PDB; 6ZM5; EM; 2.89 A; A3=1-199.
DR PDB; 6ZM6; EM; 2.59 A; A3=1-199.
DR PDB; 6ZS9; EM; 4.00 A; A3=1-199.
DR PDB; 6ZSA; EM; 4.00 A; A3=1-199.
DR PDB; 6ZSB; EM; 4.50 A; A3=1-199.
DR PDB; 6ZSC; EM; 3.50 A; A3=1-199.
DR PDB; 6ZSD; EM; 3.70 A; A3=1-199.
DR PDB; 6ZSE; EM; 5.00 A; A3=1-199.
DR PDB; 6ZSG; EM; 4.00 A; A3=1-199.
DR PDB; 7A5F; EM; 4.40 A; d6=1-199.
DR PDB; 7A5G; EM; 4.33 A; d6=1-199.
DR PDB; 7A5I; EM; 3.70 A; d6=1-199.
DR PDB; 7A5K; EM; 3.70 A; d6=1-199.
DR PDB; 7L08; EM; 3.49 A; A3=1-199.
DR PDB; 7OG4; EM; 3.80 A; A3=1-199.
DR PDBsum; 3J9M; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6RW4; -.
DR PDBsum; 6RW5; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7OG4; -.
DR AlphaFoldDB; Q9NWT8; -.
DR SMR; Q9NWT8; -.
DR BioGRID; 120331; 283.
DR ComplexPortal; CPX-5225; 28S mitochondrial small ribosomal subunit.
DR IntAct; Q9NWT8; 277.
DR STRING; 9606.ENSP00000342676; -.
DR BindingDB; Q9NWT8; -.
DR ChEMBL; CHEMBL5910; -.
DR iPTMnet; Q9NWT8; -.
DR PhosphoSitePlus; Q9NWT8; -.
DR BioMuta; AURKAIP1; -.
DR DMDM; 30912743; -.
DR EPD; Q9NWT8; -.
DR jPOST; Q9NWT8; -.
DR MassIVE; Q9NWT8; -.
DR MaxQB; Q9NWT8; -.
DR PaxDb; Q9NWT8; -.
DR PeptideAtlas; Q9NWT8; -.
DR PRIDE; Q9NWT8; -.
DR ProteomicsDB; 82979; -.
DR TopDownProteomics; Q9NWT8; -.
DR Antibodypedia; 26311; 75 antibodies from 19 providers.
DR DNASU; 54998; -.
DR Ensembl; ENST00000321751.9; ENSP00000319778.5; ENSG00000175756.14.
DR Ensembl; ENST00000338338.10; ENSP00000340656.5; ENSG00000175756.14.
DR Ensembl; ENST00000338370.7; ENSP00000342676.3; ENSG00000175756.14.
DR Ensembl; ENST00000378853.3; ENSP00000368130.3; ENSG00000175756.14.
DR GeneID; 54998; -.
DR KEGG; hsa:54998; -.
DR MANE-Select; ENST00000338338.10; ENSP00000340656.5; NM_017900.3; NP_060370.1.
DR UCSC; uc001afb.2; human.
DR CTD; 54998; -.
DR GeneCards; AURKAIP1; -.
DR HGNC; HGNC:24114; AURKAIP1.
DR HPA; ENSG00000175756; Low tissue specificity.
DR MIM; 609183; gene.
DR neXtProt; NX_Q9NWT8; -.
DR OpenTargets; ENSG00000175756; -.
DR PharmGKB; PA142672568; -.
DR VEuPathDB; HostDB:ENSG00000175756; -.
DR eggNOG; ENOG502S2YD; Eukaryota.
DR GeneTree; ENSGT00390000012802; -.
DR HOGENOM; CLU_112940_1_0_1; -.
DR InParanoid; Q9NWT8; -.
DR OMA; RHKYRKL; -.
DR OrthoDB; 1340170at2759; -.
DR PhylomeDB; Q9NWT8; -.
DR TreeFam; TF332330; -.
DR PathwayCommons; Q9NWT8; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q9NWT8; -.
DR SIGNOR; Q9NWT8; -.
DR BioGRID-ORCS; 54998; 233 hits in 1082 CRISPR screens.
DR ChiTaRS; AURKAIP1; human.
DR GenomeRNAi; 54998; -.
DR Pharos; Q9NWT8; Tchem.
DR PRO; PR:Q9NWT8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NWT8; protein.
DR Bgee; ENSG00000175756; Expressed in right testis and 204 other tissues.
DR Genevisible; Q9NWT8; HS.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IC:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006397; P:mRNA processing; IBA:GO_Central.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; NAS:UniProtKB.
DR GO; GO:0045862; P:positive regulation of proteolysis; IDA:MGI.
DR InterPro; IPR013177; COX24_C.
DR Pfam; PF08213; DUF1713; 1.
DR SMART; SM01155; DUF1713; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Nucleus; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..199
FT /note="Aurora kinase A-interacting protein"
FT /id="PRO_0000064536"
FT VARIANT 107
FT /note="Q -> H (in dbSNP:rs3736374)"
FT /id="VAR_020132"
SQ SEQUENCE 199 AA; 22354 MW; 2332CF162862477F CRC64;
MLLGRLTSQL LRAVPWAGGR PPWPVSGVLG SRVCGPLYST SPAGPGRAAS LPRKGAQLEL
EEMLVPRKMS VSPLESWLTA RCFLPRLDTG TAGTVAPPQS YQCPPSQIGE GAEQGDEGVA
DAPQIQCKNV LKIRRRKMNH HKYRKLVKKT RFLRRKVQEG RLRRKQIKFE KDLRRIWLKA
GLKEAPEGWQ TPKIYLRGK
