ID   FIU_ECO57               Reviewed;         760 AA.
AC   Q8X7W7; Q7AGC1;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Catecholate siderophore receptor Fiu;
DE   AltName: Full=Ferric iron uptake protein;
DE   AltName: Full=TonB-dependent receptor Fiu;
DE   Flags: Precursor;
GN   Name=fiu; OrderedLocusNames=Z1026, ECs0883;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in the active transport across the outer membrane of
CC       iron complexed with catecholate siderophores such as
CC       dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for
CC       transport by interacting with the trans-periplasmic membrane protein
CC       TonB. Can also transport catechol-substituted cephalosporins. Receptor
CC       for microcins M, H47 and E492 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AE005174; AAG55177.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34306.1; -; Genomic_DNA.
DR   PIR; C90739; C90739.
DR   PIR; E85589; E85589.
DR   RefSeq; NP_308910.1; NC_002695.1.
DR   RefSeq; WP_000430049.1; NZ_SEKU01000006.1.
DR   AlphaFoldDB; Q8X7W7; -.
DR   SMR; Q8X7W7; -.
DR   STRING; 155864.EDL933_0928; -.
DR   PRIDE; Q8X7W7; -.
DR   EnsemblBacteria; AAG55177; AAG55177; Z1026.
DR   EnsemblBacteria; BAB34306; BAB34306; ECs_0883.
DR   GeneID; 917629; -.
DR   KEGG; ece:Z1026; -.
DR   KEGG; ecs:ECs_0883; -.
DR   PATRIC; fig|386585.9.peg.997; -.
DR   eggNOG; COG4774; Bacteria.
DR   HOGENOM; CLU_008287_9_1_6; -.
DR   OMA; TWGSDQT; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR030148; Fiu.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR039423; TonB-dep_rcpt.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010105; TonB_sidphr_rcpt.
DR   PANTHER; PTHR32552; PTHR32552; 1.
DR   PANTHER; PTHR32552:SF68; PTHR32552:SF68; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01783; TonB-siderophor; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Receptor; Reference proteome; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..760
FT                   /note="Catecholate siderophore receptor Fiu"
FT                   /id="PRO_0000248081"
FT   MOTIF           743..760
FT                   /note="TonB C-terminal box"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   760 AA;  81956 MW;  60A294A347F7D502 CRC64;
     MENNRNFPAR QFHSLTFFAG LCIGITPVAQ ALAAEGQTNA DDTLVVEAST PSLYAPQQSA
     DPKFSRPVAD TTRTMTVISE QVIKDQGATN LTDALKNVPG VGAFFAGENG NSTTGDAIYM
     RGADTSNSIY IDGIRDIGSV SRDTFNTEQV EVIKGPSGTD YGRSAPTGSI NMISKQPRND
     SGIDASASIG SAWFRRGTLD VNQVIGDTTA VRLNVMGEKT HDAGRDKVKN ERYGVAPSIA
     FGLGTANRLY LNYLHVTQHN TPDGGIPTIG LPGYSAPSAG TATLNHSGKV DTHNFYGTDS
     DYDDSTTDTA TMRFEHDIND NTTIRNTTRW SRVKQDYLMT AIMGGASNIT QPTSDVNSWT
     WSRTANTKDV SNKILTNQTN LTSTFYTASI GHDVSTGVEF TRETQTNYGV NPVTLPAVNI
     YHPDSSIHPG GLTRNGANAN GQTDTFAIYA FDTLQITRDF ELNGGIRLDN YHTEYDSATA
     CGGSGRGAIT CPAGVAKGSP VTTVDTAKSG NLVNWKAGAL YHLTENGNVY INYAVSQQPP
     GGNNFALAQS GSGNSANRTD FKPQKANTSE IGTKWQVLDK RLLLTAALFR TDIENEVEQN
     DDGTYSQYGK KRVEGYEISV AGNITPAWQV IGGYTQQKAT IKNGKDVAQD GSSSLPYTPE
     HAFTLWSQYQ ATDDISVGAG ARYIGSMHKG SDGAVGTPAF TEGYWVADAK LGYRVNRNLD
     FQLNVYNLFD TDYVASINKS GYRYHPGEPR TFLLTANMHF