AKIP_MOUSE
ID AKIP_MOUSE Reviewed; 200 AA.
AC Q9DCJ7; Q9D1J7;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Aurora kinase A-interacting protein;
DE Short=AURKA-interacting protein;
DE AltName: Full=28S ribosomal protein S38, mitochondrial;
DE Short=MRP-S38;
GN Name=Aurkaip1; Synonyms=Aip, Akip, Mrps38;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: May act as a negative regulator of Aurora-A kinase, by down-
CC regulation through proteasome-dependent degradation.
CC -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC which comprises a 12S rRNA and about 30 distinct proteins (By
CC similarity). Interacts with Aurora-A. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Nucleus.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed and especially highly
CC expressed in heart, skeletal muscle and testis.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS38 family. {ECO:0000305}.
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DR EMBL; AK002737; BAB22317.1; -; mRNA.
DR EMBL; AK003442; BAB22792.1; -; mRNA.
DR EMBL; AK144719; BAE26030.1; -; mRNA.
DR EMBL; AK166049; BAE38543.1; -; mRNA.
DR EMBL; AL670236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS19043.1; -.
DR RefSeq; NP_079614.1; NM_025338.4.
DR RefSeq; XP_006539158.1; XM_006539095.2.
DR AlphaFoldDB; Q9DCJ7; -.
DR ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR STRING; 10090.ENSMUSP00000081114; -.
DR iPTMnet; Q9DCJ7; -.
DR PhosphoSitePlus; Q9DCJ7; -.
DR MaxQB; Q9DCJ7; -.
DR PaxDb; Q9DCJ7; -.
DR PRIDE; Q9DCJ7; -.
DR ProteomicsDB; 296152; -.
DR Antibodypedia; 26311; 75 antibodies from 19 providers.
DR DNASU; 66077; -.
DR Ensembl; ENSMUST00000084097; ENSMUSP00000081114; ENSMUSG00000065990.
DR Ensembl; ENSMUST00000105591; ENSMUSP00000101216; ENSMUSG00000065990.
DR Ensembl; ENSMUST00000105592; ENSMUSP00000101217; ENSMUSG00000065990.
DR GeneID; 66077; -.
DR KEGG; mmu:66077; -.
DR UCSC; uc008wey.2; mouse.
DR CTD; 54998; -.
DR MGI; MGI:1913327; Aurkaip1.
DR VEuPathDB; HostDB:ENSMUSG00000065990; -.
DR eggNOG; ENOG502S2YD; Eukaryota.
DR GeneTree; ENSGT00390000012802; -.
DR HOGENOM; CLU_112940_1_0_1; -.
DR InParanoid; Q9DCJ7; -.
DR OMA; RHKYRKL; -.
DR OrthoDB; 1340170at2759; -.
DR TreeFam; TF332330; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 66077; 18 hits in 72 CRISPR screens.
DR ChiTaRS; Aurkaip1; mouse.
DR PRO; PR:Q9DCJ7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9DCJ7; protein.
DR Bgee; ENSMUSG00000065990; Expressed in heart right ventricle and 263 other tissues.
DR ExpressionAtlas; Q9DCJ7; baseline and differential.
DR Genevisible; Q9DCJ7; MM.
DR GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IC:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006397; P:mRNA processing; IBA:GO_Central.
DR GO; GO:0045862; P:positive regulation of proteolysis; ISO:MGI.
DR GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR InterPro; IPR013177; COX24_C.
DR Pfam; PF08213; DUF1713; 1.
DR SMART; SM01155; DUF1713; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Nucleus; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..200
FT /note="Aurora kinase A-interacting protein"
FT /id="PRO_0000064537"
FT CONFLICT 175
FT /note="K -> R (in Ref. 1; BAB22317)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 200 AA; 23300 MW; FA26D360169CC160 CRC64;
MFLARLTSRL ARTVVPWAGF SRSCPGSGVI GSYAFRPLYS LQPASPSRAA SLPGKRTQSE
LEEFLVPRKM AISPLESWLT AQYLLPRRNV EVPVTLAPSQ FYECPPRQGE EEAQQGVREA
WDATPVQCKN VLKIRRRKMN HHKYRKLVKR TRFLRRKVRE GRLKKKQIKF EKDLKRIWLK
AGLKEAPENW QTPKIYLKNK
