ID   FIU_ECOUT               Reviewed;         760 AA.
AC   Q1REC0;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Catecholate siderophore receptor Fiu;
DE   AltName: Full=Ferric iron uptake protein;
DE   AltName: Full=TonB-dependent receptor Fiu;
DE   Flags: Precursor;
GN   Name=fiu; OrderedLocusNames=UTI89_C0808;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Involved in the active transport across the outer membrane of
CC       iron complexed with catecholate siderophores such as
CC       dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for
CC       transport by interacting with the trans-periplasmic membrane protein
CC       TonB. Can also transport catechol-substituted cephalosporins. Receptor
CC       for microcins M, H47 and E492 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; CP000243; ABE06294.1; -; Genomic_DNA.
DR   RefSeq; WP_000430008.1; NC_007946.1.
DR   AlphaFoldDB; Q1REC0; -.
DR   SMR; Q1REC0; -.
DR   EnsemblBacteria; ABE06294; ABE06294; UTI89_C0808.
DR   KEGG; eci:UTI89_C0808; -.
DR   HOGENOM; CLU_008287_9_1_6; -.
DR   OMA; TWGSDQT; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR030148; Fiu.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR039423; TonB-dep_rcpt.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010105; TonB_sidphr_rcpt.
DR   PANTHER; PTHR32552; PTHR32552; 1.
DR   PANTHER; PTHR32552:SF68; PTHR32552:SF68; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01783; TonB-siderophor; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Receptor; Signal; TonB box; Transmembrane; Transmembrane beta strand;
KW   Transport.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..760
FT                   /note="Catecholate siderophore receptor Fiu"
FT                   /id="PRO_0000248083"
FT   MOTIF           743..760
FT                   /note="TonB C-terminal box"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   760 AA;  81898 MW;  0FE4ED492D99AB5F CRC64;
     MENNRNFPAR QFHSLTFFAG LCIGITPVAQ ALAAEGQANA DDTLVVEAST PSLYAPQQSA
     DPKFSRPVAD TTRTMTVISE QVIKDQGATN LTDALKNVPG VGAFFAGENG NSTTGDAIYM
     RGADTSNSIY IDGIRDIGSV SRDTFNTEQV EVIKGPSGTD YGRSAPTGSI NMISKQPRND
     SGIDASASIG SAWFRRGTLD VNQVIGDTTA VRLNVMGEKT HDAGRDKVKN ERYGVAPSVA
     FGLGTANRLY LNYLHVTQHN TPDGGIPTIG LPGYSAPSAG TAALNHSGKV DTHNFYGTDS
     DYDDSTTDTA TMRFEHDIND NTTIRNTTRW SRVKQDYLMT AIMGGASNIT QPTSDVNSWT
     WSRTANTKDV SNKILTNQTN LTSTFYTGAI GHDVSTGVEF TRETQTNYGV NPVTLPAVNI
     YHPDSSIHPG GLTRNGANAN GQTDTFAIYA FDTLQITRDF ELNGGIRLDN YHTEYDSATA
     CGGSGRGAIT CPAGVAKGSP VTTVDTAKSG NLVNWKAGAL YHLTENGNIY INYAVSQQPP
     GGNNFALAQS GSGNSANRTD FKPQKANTSE IGTKWQVLDK RLLLTAALFR TDIENEVEQN
     DDGTYSQYGK KRVEGYEISV AGNITPAWQM IGGYTQQKAT IKNGKDVAQD GSSSLPYTPE
     HAFTLWSQYQ ATDDISVGAG ARYIGSMHKG SDGAVGTPAF TEGYWVADAK LGYRVNRNLD
     FQLNVYNLFD TDYVASINKS GYRYHPGEPR TFLLTANMHF