ID   FIXA_ECOL6              Reviewed;         256 AA.
AC   Q8FLA3;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   09-MAY-2003, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Protein FixA {ECO:0000255|HAMAP-Rule:MF_01055};
GN   Name=fixA {ECO:0000255|HAMAP-Rule:MF_01055}; OrderedLocusNames=c0050;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Required for anaerobic carnitine reduction. May bring
CC       reductant to CaiA. {ECO:0000255|HAMAP-Rule:MF_01055}.
CC   -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_01055}.
CC   -!- SUBUNIT: Heterodimer of FixA and FixB. {ECO:0000255|HAMAP-
CC       Rule:MF_01055}.
CC   -!- SIMILARITY: Belongs to the ETF beta-subunit/FixA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01055}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN78548.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN78548.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000692217.1; NC_004431.1.
DR   AlphaFoldDB; Q8FLA3; -.
DR   SMR; Q8FLA3; -.
DR   STRING; 199310.c0050; -.
DR   EnsemblBacteria; AAN78548; AAN78548; c0050.
DR   KEGG; ecc:c0050; -.
DR   eggNOG; COG2086; Bacteria.
DR   HOGENOM; CLU_060196_2_2_6; -.
DR   OMA; ADLNEWD; -.
DR   UniPathway; UPA00117; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0009437; P:carnitine metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01714; ETF_beta; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_01055; FixA; 1.
DR   InterPro; IPR000049; ET-Flavoprotein_bsu_CS.
DR   InterPro; IPR014730; ETF_a/b_N.
DR   InterPro; IPR012255; ETF_b.
DR   InterPro; IPR033948; ETF_beta_N.
DR   InterPro; IPR023463; FixA.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR21294; PTHR21294; 1.
DR   Pfam; PF01012; ETF; 1.
DR   PIRSF; PIRSF000090; Beta-ETF; 1.
DR   SMART; SM00893; ETF; 1.
DR   PROSITE; PS01065; ETF_BETA; 1.
PE   3: Inferred from homology;
KW   Electron transport; Transport.
FT   CHAIN           1..256
FT                   /note="Protein FixA"
FT                   /id="PRO_0000167893"
SQ   SEQUENCE   256 AA;  27172 MW;  59B261D9F62FD306 CRC64;
     MKIITCYKCV PDEQDIAVNN ADGSLDFSKA DAKISQYDLN AIEAACQLKQ QAAEAQVTAL
     SVGGKALTNA KGRKDVLSRG PDELIVVIDD QFEQALPQQT ASVLAAAAQK AGFDLILCGD
     GSSDLYAQQV GLLVGEILNI PAVNGVSKII SLTADTLTVE RELEDETETL SIPLPAVVAV
     STDINSPQIP SMKAILGAAK KPVQVWSAAD IGFNAEAAWS EQQVAAPKQR ERQRIVIEGD
     GEEQIAAFAE NLRKVI