ID   FIXC_SHIFL              Reviewed;         428 AA.
AC   Q83SQ7; Q7C3B9;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Protein FixC;
GN   Name=fixC; OrderedLocusNames=SF0040, S0042;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Could be part of an electron transfer system required for
CC       anaerobic carnitine reduction. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305};
CC   -!- SIMILARITY: Belongs to the ETF-QO/FixC family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN41706.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP15586.1; -; Genomic_DNA.
DR   RefSeq; NP_705999.1; NC_004337.2.
DR   RefSeq; WP_001287727.1; NZ_WPGW01000005.1.
DR   AlphaFoldDB; Q83SQ7; -.
DR   SMR; Q83SQ7; -.
DR   STRING; 198214.SF0040; -.
DR   EnsemblBacteria; AAN41706; AAN41706; SF0040.
DR   EnsemblBacteria; AAP15586; AAP15586; S0042.
DR   GeneID; 1024551; -.
DR   KEGG; sfl:SF0040; -.
DR   KEGG; sft:NCTC1_00040; -.
DR   KEGG; sfx:S0042; -.
DR   PATRIC; fig|198214.7.peg.48; -.
DR   HOGENOM; CLU_050977_0_0_6; -.
DR   OMA; GEWAVRI; -.
DR   OrthoDB; 1770293at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR039651; FixC-like.
DR   PANTHER; PTHR43624; PTHR43624; 1.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Transport.
FT   CHAIN           1..428
FT                   /note="Protein FixC"
FT                   /id="PRO_0000200695"
SQ   SEQUENCE   428 AA;  45654 MW;  4CD1D35C87B97FBD CRC64;
     MSEDIFDAII VGAGLAGSVA ALVLAREGAQ VLVIERGNSA GAKNVTGGRL YAHSLEHIIP
     GFADSAPVER LITHEKLAFM TEKSAMTMDY CNGDETSPSQ RSYSVLRSKF DAWLMEQAEE
     AGAQLITGIR VDNLVQRDGK VVGVEADGDV IEAKTVLLAD GVNSILAEKL GMAKRVKPTD
     VAVGVKELIE LPKSVIEDRF QLQGNQGAAC LFAGSPTDGL MGGGFLYTNE NTLSLGLVCG
     LHHLHDAKKS VPQMLEDFKQ HPAVAPLIAG GKLVEYSAHV VPEAGINMLP ELVGDGVLIA
     GDAAGMCMNL GFTIRGMDLA IAAGEAAAKT VLSAMKSDDF SKQKLAEYRQ HLESGPLRDM
     RMYQKLPAFL DNPRMFSGNP ELAVGVARDL FTIDGSAPEL MRKKILRHGK KVGFINLIKD
     GMKGVTVL