FJX1_HUMAN
ID FJX1_HUMAN Reviewed; 437 AA.
AC Q86VR8; B2RCA9; Q9UGK6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Four-jointed box protein 1;
DE AltName: Full=Four-jointed protein homolog;
DE Flags: Precursor;
GN Name=FJX1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal kidney;
RX PubMed=10568747; DOI=10.1101/gr.9.11.1074;
RA Gawin B., Niederfuehr A., Schumacher N., Hummerich H., Little P.F.R.,
RA Gessler M.;
RT "A 7.5 Mb sequence-ready PAC contig and gene expression map of human
RT chromosome 11p13-p14.1.";
RL Genome Res. 9:1074-1086(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as an inhibitor of dendrite extension and branching.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- PTM: Undergoes proteolytic cleavage. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FJX1/FJ family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB53246.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ245599; CAB53246.1; ALT_FRAME; mRNA.
DR EMBL; AK315015; BAG37506.1; -; mRNA.
DR EMBL; CH471064; EAW68138.1; -; Genomic_DNA.
DR EMBL; BC049171; AAH49171.1; -; mRNA.
DR EMBL; BC071898; AAH71898.1; -; mRNA.
DR CCDS; CCDS44570.1; -.
DR RefSeq; NP_055159.2; NM_014344.3.
DR AlphaFoldDB; Q86VR8; -.
DR SMR; Q86VR8; -.
DR BioGRID; 117297; 5.
DR IntAct; Q86VR8; 2.
DR STRING; 9606.ENSP00000400223; -.
DR GlyGen; Q86VR8; 1 site.
DR iPTMnet; Q86VR8; -.
DR PhosphoSitePlus; Q86VR8; -.
DR BioMuta; FJX1; -.
DR DMDM; 74727610; -.
DR MassIVE; Q86VR8; -.
DR PaxDb; Q86VR8; -.
DR PeptideAtlas; Q86VR8; -.
DR PRIDE; Q86VR8; -.
DR ProteomicsDB; 70063; -.
DR Antibodypedia; 25981; 87 antibodies from 23 providers.
DR DNASU; 24147; -.
DR Ensembl; ENST00000317811.6; ENSP00000400223.1; ENSG00000179431.7.
DR GeneID; 24147; -.
DR KEGG; hsa:24147; -.
DR MANE-Select; ENST00000317811.6; ENSP00000400223.1; NM_014344.4; NP_055159.2.
DR UCSC; uc001mwh.4; human.
DR CTD; 24147; -.
DR DisGeNET; 24147; -.
DR GeneCards; FJX1; -.
DR HGNC; HGNC:17166; FJX1.
DR HPA; ENSG00000179431; Low tissue specificity.
DR MIM; 612206; gene.
DR neXtProt; NX_Q86VR8; -.
DR OpenTargets; ENSG00000179431; -.
DR PharmGKB; PA28151; -.
DR VEuPathDB; HostDB:ENSG00000179431; -.
DR eggNOG; ENOG502QUJ4; Eukaryota.
DR GeneTree; ENSGT00390000016768; -.
DR HOGENOM; CLU_033850_0_0_1; -.
DR InParanoid; Q86VR8; -.
DR OMA; YRRHEPR; -.
DR OrthoDB; 1414662at2759; -.
DR PhylomeDB; Q86VR8; -.
DR TreeFam; TF324767; -.
DR PathwayCommons; Q86VR8; -.
DR SignaLink; Q86VR8; -.
DR BioGRID-ORCS; 24147; 14 hits in 1070 CRISPR screens.
DR ChiTaRS; FJX1; human.
DR GenomeRNAi; 24147; -.
DR Pharos; Q86VR8; Tbio.
DR PRO; PR:Q86VR8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q86VR8; protein.
DR Bgee; ENSG00000179431; Expressed in ventricular zone and 141 other tissues.
DR Genevisible; Q86VR8; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0010842; P:retina layer formation; IEA:Ensembl.
DR InterPro; IPR024868; FJX1/FJ.
DR PANTHER; PTHR13147; PTHR13147; 1.
DR PRINTS; PR02072; 4JOINTEDBOX1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..437
FT /note="Four-jointed box protein 1"
FT /id="PRO_0000333045"
FT REGION 33..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 153
FT /note="M -> L (in dbSNP:rs12792700)"
FT /id="VAR_043117"
FT VARIANT 415
FT /note="R -> H (in dbSNP:rs12286850)"
FT /id="VAR_062233"
FT CONFLICT 58
FT /note="P -> R (in Ref. 1; CAB53246)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 437 AA; 48507 MW; 3E2B8D3977722639 CRC64;
MGRRMRGAAA TAGLWLLALG SLLALWGGLL PPRTELPASR PPEDRLPRRP ARSGGPAPAP
RFPLPPPLAW DARGGSLKTF RALLTLAAGA DGPPRQSRSE PRWHVSARQP RPEESAAVHG
GVFWSRGLEE QVPPGFSEAQ AAAWLEAARG ARMVALERGG CGRSSNRLAR FADGTRACVR
YGINPEQIQG EALSYYLARL LGLQRHVPPL ALARVEARGA QWAQVQEELR AAHWTEGSVV
SLTRWLPNLT DVVVPAPWRS EDGRLRPLRD AGGELANLSQ AELVDLVQWT DLILFDYLTA
NFDRLVSNLF SLQWDPRVMQ RATSNLHRGP GGALVFLDNE AGLVHGYRVA GMWDKYNEPL
LQSVCVFRER TARRVLELHR GQDAAARLLR LYRRHEPRFP ELAALADPHA QLLQRRLDFL
AKHILHCKAK YGRRSGT
