ID   FJX1_XIPMA              Reviewed;         427 AA.
AC   Q5ZEQ8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Four-jointed box protein 1;
DE   AltName: Full=Four-jointed protein homolog;
DE   Flags: Precursor;
GN   Name=fjx1;
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16145673; DOI=10.1002/dvdy.20553;
RA   Rock R., Heinrich A.C., Schumacher N., Gessler M.;
RT   "Fjx1: a notch-inducible secreted ligand with specific binding sites in
RT   developing mouse embryos and adult brain.";
RL   Dev. Dyn. 234:602-612(2005).
CC   -!- FUNCTION: May act as an inhibitor of dendrite extension and branching.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; AJ849641; CAH61084.1; -; Genomic_DNA.
DR   RefSeq; XP_005802291.1; XM_005802234.1.
DR   AlphaFoldDB; Q5ZEQ8; -.
DR   STRING; 8083.ENSXMAP00000020297; -.
DR   Ensembl; ENSXMAT00000020325; ENSXMAP00000020297; ENSXMAG00000020250.
DR   eggNOG; ENOG502QUJ4; Eukaryota.
DR   GeneTree; ENSGT00390000016768; -.
DR   HOGENOM; CLU_033850_0_0_1; -.
DR   InParanoid; Q5ZEQ8; -.
DR   OMA; YRRHEPR; -.
DR   OrthoDB; 1414662at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024868; FJX1/FJ.
DR   PANTHER; PTHR13147; PTHR13147; 1.
DR   PRINTS; PR02072; 4JOINTEDBOX1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..427
FT                   /note="Four-jointed box protein 1"
FT                   /id="PRO_0000333047"
FT   CARBOHYD        81
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        244
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        270
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   427 AA;  48334 MW;  CF6CF31CCBF7F63C CRC64;
     MRALSANLFA VLLMCALASV FYVWSALENR LERHKRGSSV PDGGSFHQGP SEDHSAKTFR
     ALLAVPVAQR QNSAGRSKAQ NLTNPSAFVG SRDYHVNGDD ERSAQREGPV KLGYPVDDGI
     FWSNWLEDVL PVRFTEGYAE AWRSKARTSP VVKLEPGCGR ISNQLATFAD GTKACVRYGI
     NADQVQGETL TYYLASLLGI TNLPPLVLSQ LNGDSAQWVA VRTRINNLQW SDRAVVSLTE
     WISNLTGVVT PAPLRQESSG LLPALRCFEN KTTAELLELM QWSDLIVFDY LTANFDRLVS
     NLFSLQWDPH VMERDTNNLL KTPHGDLVFI DNEAGLVHGF RVLNMWEKYH HSVLSSVCVF
     RKRTMQRVAE LHRRRDSRQR LLELYRDSEP LSQELGFLSD EHAAVLQDRI DQLYKHIMQC
     KEKYNQL